{"id":"W2106318552","doi":"10.1016/j.molcel.2015.08.013","title":"Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth","year":2015,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Terry Fox Foundation; Canadian Institutes of Health Research; Cancer Research Society; Cancer Research UK; Wellcome Trust; McGill University","keywords":"Biology; Phosphoenolpyruvate carboxykinase; Glutamine; Cell growth; Citric acid cycle; Gluconeogenesis; Biochemistry; Metabolic pathway; Glycolysis; Glutaminolysis; Anaerobic glycolysis; Carbohydrate metabolism; Glucose uptake; Cell biology; Metabolism; Endocrinology; Amino acid; Enzyme; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001784658,0.0003026526,0.0002923141,0.00007882894,0.00007577086,0.00007372681,0.0002004915,0.0001581393,0.000009782017],"category_scores_gemma":[0.00007563347,0.0003031095,0.0001279839,0.000134066,0.0000909485,0.00001179842,0.000156986,0.0001207448,0.00001426747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001882032,"about_ca_system_score_gemma":0.00020684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004502819,"about_ca_topic_score_gemma":0.00007397129,"domain_scores_codex":[0.9982998,0.0001070612,0.0002690493,0.0006026673,0.0003147724,0.000406622],"domain_scores_gemma":[0.9989178,0.000006046205,0.0001324206,0.0004265591,0.0002082571,0.0003089139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002072564,0.00007496592,0.00008129156,0.00002478237,0.00005682525,0.00002416395,0.0002210878,0.0001938141,0.9955271,0.000277629,0.00175732,0.001553756],"study_design_scores_gemma":[0.002037198,0.000142947,0.0001983705,0.000007409328,0.0001073739,0.0000258849,0.0002013999,0.0001538532,0.8512608,0.0004012782,0.1451301,0.0003333511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453201,0.0491741,0.001910971,0.00007416096,0.001330879,0.0003630931,0.00002661857,0.00003221121,0.00176783],"genre_scores_gemma":[0.9935868,0.001364241,0.002555188,0.0003990488,0.0009723372,0.00005863166,0.0001420951,0.00006590122,0.0008557872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1442663,"threshold_uncertainty_score":0.9999421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009712290056166513,"score_gpt":0.205708239749179,"score_spread":0.1959959496930125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}