{"id":"W2106381897","doi":"10.1128/mcb.20.23.9076-9083.2000","title":"Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of <i>mec1</i> and <i>rad53</i> Lethality","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Metal-Catalyzed Oxygenation Mechanisms","field":"Chemistry","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute of General Medical Sciences; National Institutes of Health; Royal Swedish Academy of Sciences; Alexander and Margaret Stewart Trust","keywords":"Biology; Ribonucleotide reductase; Lethality; Genetics; Domain (mathematical analysis); Mutation; Molecular biology; Gene; Protein subunit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008717252,0.0004214561,0.000146728,0.0001332326,0.000136945,0.0001388695,0.0002028105,0.0002308324,0.0005854507],"category_scores_gemma":[0.0001313737,0.00010198,0.0001766535,0.00009828761,0.0002211546,0.00008409326,0.0001532972,0.0003452833,0.0004256504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003831802,"about_ca_system_score_gemma":0.0001379794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006682561,"about_ca_topic_score_gemma":0.0009569994,"domain_scores_codex":[0.9999495,0.00001315947,0.000004032294,0.000008146319,0.00001733841,0.00000787393],"domain_scores_gemma":[0.9999148,0.00001676951,0.00004237585,0.000004648064,0.00000603894,0.00001535055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009052734,0.00003260498,0.0004445057,0.00004638024,0.00000657902,0.0001312489,0.00001345766,0.0004100052,0.9971409,0.0001632628,0.0000249981,0.001495615],"study_design_scores_gemma":[0.00001422,0.0001503627,0.007231097,0.000009561601,0.00002115459,0.0005449601,0.00002632777,0.00264373,0.9870227,0.00007145839,0.002256155,0.000008254683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961068,0.0007159404,0.002118684,0.00005259154,0.000007013703,0.00001675616,0.000147271,0.00003322384,0.0008016321],"genre_scores_gemma":[0.9959215,0.0004332695,0.002411308,0.00003121713,0.000004415832,0.00001398242,0.0004604456,0.00001739033,0.0007063649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006682561,"threshold_uncertainty_score":0.002780199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01475880726265416,"score_gpt":0.2717232433119054,"score_spread":0.2569644360492513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}