{"id":"W2106387716","doi":"10.1517/17425250802560279","title":"Pharmacogenetics and the serotonin transporter in late-life depression","year":2008,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Serotonin transporter; Antidepressant; Depression (economics); Pharmacogenetics; Paroxetine; Serotonin; Medicine; Psychology; 5-HTTLPR; Psychiatry; Genotype; Internal medicine; Genetics; Biology; Gene; Anxiety; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003562536,0.0009677178,0.002510696,0.0005166456,0.000258036,0.00006400108,0.001189766,0.0005423176,0.0003129948],"category_scores_gemma":[0.0001572476,0.0006315297,0.0005535322,0.0006123502,0.0009156215,0.0001725361,0.0001496632,0.001511694,0.0001534461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005742257,"about_ca_system_score_gemma":0.0002460824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002253289,"about_ca_topic_score_gemma":0.000003210202,"domain_scores_codex":[0.9929311,0.002771522,0.001352519,0.001544789,0.0005933764,0.0008067522],"domain_scores_gemma":[0.9974009,0.0009461819,0.0004977259,0.0008153498,0.00002613577,0.0003137554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003332771,0.000529791,0.00002610169,0.0005010242,0.00003107051,0.0001800197,0.003362656,0.00003114262,0.002401514,0.0003629391,0.001876153,0.9903643],"study_design_scores_gemma":[0.002866185,0.00003081283,0.00008591618,0.0008212785,0.0000354321,0.0001592738,0.000009317115,0.00002010437,0.004383449,0.00001730303,0.9909739,0.0005969597],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006037465,0.9860235,0.000006583471,0.0006567433,0.003405124,0.003519432,0.00005956804,0.0001147077,0.0001768092],"genre_scores_gemma":[0.0009363439,0.9900727,0.0000515751,0.006071799,0.0003983635,0.002154246,0.00001424282,0.0001569503,0.0001438242],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9897674,"threshold_uncertainty_score":0.9996136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07519045788432875,"score_gpt":0.3714474857813355,"score_spread":0.2962570278970068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}