{"id":"W2106428814","doi":"10.1371/journal.pone.0134952","title":"Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; National and Kapodistrian University of Athens; General Secretariat for Research and Technology; Institut National de la Santé et de la Recherche Médicale; Ontario Ministry of Economic Development and Innovation; Genome Canada; Wellcome Trust; GlaxoSmithKline; Pfizer; Eli Lilly and Company","keywords":"Peptide; Integrin; Chemistry; Platelet Glycoprotein GPIIb-IIIa Complex; Biophysics; Ligand (biochemistry); Biochemistry; Stereochemistry; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004249,0.0002862154,0.0002443483,0.00007451906,0.00009677327,0.0001756484,0.000202562,0.000244435,0.00147185],"category_scores_gemma":[0.00007555934,0.0001050024,0.0002521572,0.00009853629,0.0001611258,0.00008448807,0.0001455931,0.0004131507,0.0004320823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001302817,"about_ca_system_score_gemma":0.00009902648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001913636,"about_ca_topic_score_gemma":0.0002146547,"domain_scores_codex":[0.9999361,0.00001327674,0.000003976542,0.00001421414,0.00001655118,0.00001588069],"domain_scores_gemma":[0.9999565,0.000008310315,0.0000177177,0.000003191476,0.000003241128,0.000010995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001369544,0.00001731899,0.00006945146,0.00002962344,0.000005480177,0.0000554709,0.000006020709,0.0001130772,0.9985821,0.00004457471,0.0000153283,0.0009245931],"study_design_scores_gemma":[0.00007570168,0.0009104982,0.00283234,0.00001077634,0.00002419448,0.0007093449,0.00002011492,0.001728724,0.990573,0.00005654964,0.003050668,0.000008115282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939998,0.00137659,0.003298033,0.00005813695,0.00002096748,0.00002880665,0.0001148069,0.00004100749,0.001061882],"genre_scores_gemma":[0.9945275,0.0007640436,0.00328225,0.00006617782,0.000007232446,0.00002030501,0.0002492414,0.00001577766,0.00106748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00147185,"threshold_uncertainty_score":0.00492382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05091119788046914,"score_gpt":0.2530533517443277,"score_spread":0.2021421538638586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}