{"id":"W2106429495","doi":"10.1371/journal.pone.0082164","title":"Broad-Scale Phosphoprotein Profiling of Beta Adrenergic Receptor (β-AR) Signaling Reveals Novel Phosphorylation and Dephosphorylation Events","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health; Donald E. and Delia B. Baxter Foundation; Lupus Research Alliance; National Institute of Allergy and Infectious Diseases; European Commission; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada","keywords":"Dephosphorylation; Phosphorylation; CREB; Signal transduction; Biology; Forskolin; Adenylyl cyclase; Cell biology; Protein kinase B; Activator (genetics); Phosphatase; Receptor; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140598,0.0003322677,0.0003077079,0.0004561619,0.0002036828,0.000324849,0.0001451137,0.0002765017,0.001047642],"category_scores_gemma":[0.00007411517,0.0001568662,0.0003744851,0.0004124801,0.0001275577,0.0002368124,0.0001664754,0.0005985609,0.0004192227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001656011,"about_ca_system_score_gemma":0.0001121031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003591146,"about_ca_topic_score_gemma":0.000893069,"domain_scores_codex":[0.999886,0.000006044177,0.000006629252,0.00004659276,0.0000293791,0.00002536226],"domain_scores_gemma":[0.9999427,0.00001020258,0.00001970285,0.000003854414,0.00001060859,0.00001300819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000734425,0.00001220329,0.0006140779,0.00004644744,0.000007980471,0.00002626061,0.0000128296,0.00004454704,0.9979698,0.00002519835,0.00005647785,0.001110825],"study_design_scores_gemma":[0.00001323585,0.0003522256,0.131016,0.00001475399,0.00007459094,0.0004838038,0.0001021323,0.002087428,0.8622373,0.0001808931,0.00341963,0.00001809824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791219,0.003993719,0.009947578,0.0001605967,0.00005713018,0.00004789785,0.004476509,0.0001522,0.002042557],"genre_scores_gemma":[0.9665432,0.006331597,0.01531255,0.0003008966,0.00005768894,0.0002053506,0.006917622,0.00005589959,0.004275163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047642,"threshold_uncertainty_score":0.003504694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01805150030727436,"score_gpt":0.2066650981026685,"score_spread":0.1886135977953941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}