{"id":"W2106449126","doi":"10.4049/jimmunol.173.5.2909","title":"Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":1634,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; Université de Montréal; McGill University","funders":"","keywords":"Cathelicidin; Antimicrobial peptides; Antimicrobial; Beta defensin; Biology; Calcitriol receptor; Innate immune system; Gene expression; Peptide; Defensin; Immune system; Microbiology; Gene; Cell biology; Molecular biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001497094,0.000247095,0.0003299249,0.0002476863,0.0001571428,0.000856322,0.0003663421,0.001077414,0.007930757],"category_scores_gemma":[0.0002134587,0.000160653,0.0002832753,0.0003044159,0.0003450097,0.0002559186,0.0002739731,0.0006428185,0.003024476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003699189,"about_ca_system_score_gemma":0.0002338462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002740094,"about_ca_topic_score_gemma":0.0003623385,"domain_scores_codex":[0.9998173,0.00001443638,0.00001566135,0.00005859578,0.0000674349,0.00002662524],"domain_scores_gemma":[0.9998597,0.00003979967,0.00002892054,0.00001356473,0.00003201927,0.00002593239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005307868,0.00009241178,0.0008158823,0.001993747,0.00003973057,0.0004318403,0.00003216363,0.00008706628,0.901508,0.002326668,0.008187297,0.08395433],"study_design_scores_gemma":[0.0001554332,0.001075068,0.01480275,0.0002163233,0.0001252429,0.002878328,0.0001683326,0.0004274272,0.5286717,0.002353942,0.4490979,0.00002750148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2668365,0.6316073,0.02030602,0.01122146,0.008319849,0.0002941242,0.004829597,0.001209431,0.05537586],"genre_scores_gemma":[0.7868405,0.1497318,0.009265951,0.006627826,0.001997302,0.0001516465,0.003964795,0.0001075693,0.04131271],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007930757,"threshold_uncertainty_score":0.02653104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111355538943396,"score_gpt":0.2278294674798463,"score_spread":0.2167159120904124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}