{"id":"W2106473601","doi":"10.1371/journal.pone.0008570","title":"Structural Biology of Human H3K9 Methyltransferases","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Methyltransferase; Methylation; Epigenetics; Histone; Docking (animal); Computational biology; Histone methyltransferase; Histone methylation; Plug-in; Biology; Chemistry; DNA methylation; Genetics; Computer science; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176487,0.0004130577,0.0001975243,0.00009483283,0.0002140026,0.0002758445,0.0006310921,0.0004022457,0.002456803],"category_scores_gemma":[0.000177854,0.0001581223,0.0002863248,0.0001464055,0.0001804855,0.0002648874,0.0001995165,0.000497327,0.0004255338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000717053,"about_ca_system_score_gemma":0.0002741641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001991191,"about_ca_topic_score_gemma":0.002350267,"domain_scores_codex":[0.9999512,0.00000637607,0.000002031077,0.00001530001,0.00001636066,0.000008745428],"domain_scores_gemma":[0.9999604,0.00001078014,0.000009064995,0.000003875027,0.000006671104,0.000009142429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001107161,0.0002113388,0.009462369,0.0008126394,0.000176569,0.0008441164,0.0004486428,0.05747181,0.8764362,0.01252883,0.003513595,0.03698666],"study_design_scores_gemma":[0.0003374942,0.0008535577,0.03438738,0.00009327452,0.0002315501,0.001926954,0.0004880142,0.2369831,0.6710712,0.01266943,0.04086851,0.0000895491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755659,0.00437361,0.01330441,0.0008845562,0.00009133738,0.00002284391,0.0005933821,0.0003131056,0.004850982],"genre_scores_gemma":[0.9912088,0.00107576,0.004918734,0.00008670601,0.00001233558,0.00001106361,0.000969104,0.00002101908,0.001696608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002456803,"threshold_uncertainty_score":0.008218884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343162269740666,"score_gpt":0.2622631106316554,"score_spread":0.2388314879342487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}