{"id":"W2106473601","doi":"10.1371/journal.pone.0008570","title":"Structural Biology of Human H3K9 Methyltransferases","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Methyltransferase; Methylation; Epigenetics; Histone; Docking (animal); Computational biology; Histone methyltransferase; Histone methylation; Plug-in; Biology; Chemistry; DNA methylation; Genetics; Computer science; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000547727,0.00007887523,0.0001259147,0.00003271932,0.00003579824,0.000003341123,0.00009878871,0.0001638863,0.0001337171],"category_scores_gemma":[0.00003819635,0.00007709285,0.00004731499,0.00004843701,0.0001002012,0.000001649987,0.00002405241,0.00009114466,0.000002766181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003722786,"about_ca_system_score_gemma":0.00002467737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004035162,"about_ca_topic_score_gemma":0.0001662542,"domain_scores_codex":[0.9994721,0.00002378256,0.0001448062,0.0001749122,0.00007042214,0.0001139104],"domain_scores_gemma":[0.9995841,0.000006877411,0.00004556138,0.0002521229,0.00007731969,0.00003405041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002105549,0.00006433732,0.004423243,0.00001727688,0.0001152181,7.695822e-8,0.00001614113,0.000005036403,0.9941884,0.0002705819,0.00002632578,0.0008523261],"study_design_scores_gemma":[0.0002736961,0.0002287263,0.005639583,0.000007511308,0.00004670119,0.00000116132,0.000003822022,0.00003101731,0.9931659,0.0003476811,0.0001659542,0.00008828143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990259,0.0002550706,0.00004418821,0.00007335388,0.00007290645,0.0001129951,0.00002701959,0.00001013743,0.0003784078],"genre_scores_gemma":[0.9984486,0.00002938224,0.0008990386,0.00001840677,0.0002473955,0.000007601145,0.0001884069,0.00001242319,0.0001488179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121634,"threshold_uncertainty_score":0.3143755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343162269740666,"score_gpt":0.2622631106316554,"score_spread":0.2388314879342487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}