{"id":"W2106503032","doi":"10.1210/jc.2005-2157","title":"Mitotane Has an Estrogenic Effect on Sex Hormone-Binding Globulin and Corticosteroid-Binding Globulin in Humans","year":2006,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University","keywords":"Sex hormone-binding globulin; Endocrinology; Internal medicine; Mitotane; Globulin; Transcortin; Estrogen; Transfection; CYP17A1; Hormone; Chemistry; Cell culture; Biology; Medicine; Androgen; Adrenocortical carcinoma; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716113,0.0001689441,0.0002054529,0.0002098431,0.0001282354,0.0002784812,0.00006844082,0.0001868036,0.001731902],"category_scores_gemma":[0.0003952295,0.00008981113,0.0001638986,0.0001770373,0.0002749845,0.0001211465,0.0001206934,0.0001263115,0.0002550679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002209638,"about_ca_system_score_gemma":0.0001319982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008646008,"about_ca_topic_score_gemma":0.0008312434,"domain_scores_codex":[0.9998974,0.00003613126,0.000007812255,0.00002059005,0.00002537898,0.00001264295],"domain_scores_gemma":[0.999803,0.00006632493,0.00006363539,0.00002033198,0.00001430931,0.00003238316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007173366,0.0002580243,0.2828637,0.000692647,0.0004967199,0.00183024,0.0001737527,0.0005623155,0.6139435,0.0008629126,0.0006131906,0.0905297],"study_design_scores_gemma":[0.0002333633,0.009179331,0.8729202,0.0000595634,0.0003037196,0.008770276,0.0002399797,0.0006184393,0.09023543,0.0003505062,0.01706764,0.000021558],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709743,0.02501252,0.001159172,0.0001480372,0.00002246512,0.00001730291,0.0001451685,0.00004035265,0.002480659],"genre_scores_gemma":[0.9974003,0.001878064,0.000175618,0.00005326873,0.00001327901,0.000005154469,0.00004900219,0.000002100924,0.0004232719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001731902,"threshold_uncertainty_score":0.00579381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05118215881543389,"score_gpt":0.3641256849335198,"score_spread":0.312943526118086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}