{"id":"W2106554399","doi":"10.1194/jlr.m700554-jlr200","title":"Cholesterol supply and SREBPs modulate transcription of the Niemann-Pick C-1 gene in steroidogenic tissues","year":2008,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Cegep de Saint Hyacinthe","funders":"","keywords":"Sterol regulatory element-binding protein; Chromatin immunoprecipitation; Transactivation; Promoter; Sterol; Biology; Transcription factor; Molecular biology; Gene; Gene expression; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001680841,0.0001262029,0.0004836606,0.0004753054,0.00008999049,0.00001903964,0.0002396309,0.0001109818,0.00004448451],"category_scores_gemma":[0.0001316351,0.0000783896,0.0001623375,0.0004282136,0.0002974864,0.0002027285,0.00007047801,0.0009060709,0.000004620106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005808963,"about_ca_system_score_gemma":0.0001664392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006548628,"about_ca_topic_score_gemma":0.00002981657,"domain_scores_codex":[0.9973931,0.0003620327,0.0006975015,0.0001660162,0.001047523,0.0003338717],"domain_scores_gemma":[0.9988557,0.0000753909,0.0001823913,0.0002996596,0.0004026263,0.0001842839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007310772,0.0004416432,0.1801654,0.0001988318,0.00008770722,0.0000672097,0.005009553,0.00004563136,0.80232,0.00001537142,0.001044246,0.009873323],"study_design_scores_gemma":[0.004295552,0.000573671,0.9093192,0.0003935441,0.00003740673,0.001715292,0.0002416941,0.00007887659,0.07163533,0.00004941514,0.01158686,0.00007317604],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936421,0.002474659,0.00001463336,0.003066227,0.0003449172,0.0003115241,0.000004564721,0.000003619187,0.0001377387],"genre_scores_gemma":[0.9944071,0.003143298,0.0002168761,0.0001008717,0.0008646457,0.000003710304,8.973619e-7,0.00002013064,0.001242541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7306846,"threshold_uncertainty_score":0.3936478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07849050971176157,"score_gpt":0.3415859123345476,"score_spread":0.263095402622786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}