{"id":"W2106610000","doi":"10.4049/jimmunol.1103113","title":"Pleiotropic IFN-Dependent and -Independent Effects of IRF5 on the Pathogenesis of Experimental Lupus","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of Toronto","keywords":"IRF5; TLR7; Immunology; Systemic lupus erythematosus; Biology; TLR9; Chemokine; Cytokine; Plasmacytoid dendritic cell; Interferon regulatory factors; Autoimmunity; Inflammation; Toll-like receptor; Dendritic cell; Medicine; Innate immune system; Internal medicine; Immune system; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004021205,0.0007224834,0.0002645018,0.0004071838,0.0001220839,0.0002069447,0.0001946241,0.000467218,0.001157385],"category_scores_gemma":[0.0001753422,0.0001675423,0.00042212,0.00009606155,0.000335455,0.0002470225,0.0002367955,0.0007473447,0.0002103098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001636572,"about_ca_system_score_gemma":0.0001043338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009732297,"about_ca_topic_score_gemma":0.0001835973,"domain_scores_codex":[0.9996353,0.0001216911,0.00004208209,0.00006435653,0.00006404935,0.00007248508],"domain_scores_gemma":[0.9997407,0.00003711199,0.0001063004,0.00003874221,0.00001591529,0.00006125043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009542453,0.00009186703,0.002624693,0.0000599671,0.00001529153,0.000271294,0.00002121288,0.00006215679,0.9931378,0.0001324548,0.00002823508,0.002600894],"study_design_scores_gemma":[0.0001876853,0.002692955,0.1001963,0.00006518657,0.0001790238,0.003917483,0.0001232299,0.001602072,0.8880462,0.0003927315,0.002576766,0.00002045947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957849,0.002103669,0.0009576875,0.0000816281,0.00001774595,0.00001694474,0.0001714836,0.00004909093,0.0008169352],"genre_scores_gemma":[0.9979814,0.0005077007,0.0008452033,0.00005654674,0.00001509488,0.00001828983,0.000126288,0.00001031263,0.0004391335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157385,"threshold_uncertainty_score":0.003871799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783712011833769,"score_gpt":0.2813712248991007,"score_spread":0.2635341047807629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}