{"id":"W2106613407","doi":"10.1093/aje/kwp275","title":"Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Colorectal Cancer: A HuGE-GSEC Review","year":2009,"lang":"en","type":"review","venue":"American Journal of Epidemiology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute on Minority Health and Health Disparities; National Cancer Institute; National Center for Research Resources; Cancer Research UK","keywords":"Methylenetetrahydrofolate reductase; Odds ratio; Medicine; Confidence interval; Internal medicine; Colorectal cancer; Meta-analysis; Genotype; Body mass index; Population; Demography; Gastroenterology; Oncology; Cancer; Genetics; Biology; Environmental health; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01167379,0.002805402,0.01444296,0.006236514,0.0004619542,0.002907877,0.001705278,0.001829883,0.004063374],"category_scores_gemma":[0.02419022,0.00130795,0.03263124,0.006991387,0.0004121556,0.001209782,0.001344958,0.001530418,0.0004259967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001722029,"about_ca_system_score_gemma":0.002506219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005596539,"about_ca_topic_score_gemma":0.01311365,"domain_scores_codex":[0.9929798,0.003582885,0.001711562,0.0006975556,0.0008149568,0.0002132015],"domain_scores_gemma":[0.983946,0.01226988,0.00181682,0.0005988106,0.001216269,0.0001523114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00159978,0.00003295216,0.006048963,0.254428,0.6999817,0.0002371134,0.00005880792,0.00105306,0.0003230477,0.0002755345,0.002936253,0.03302476],"study_design_scores_gemma":[0.0003253864,0.0001382564,0.005174272,0.02142192,0.9669598,0.0001849403,0.00003292953,0.0002765968,0.0001245628,0.0003632483,0.004970134,0.00002801516],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001591624,0.9971327,0.0002728691,0.0002127628,0.0001293474,0.00006294031,0.0004050015,0.00001656767,0.0001763043],"genre_scores_gemma":[0.05430556,0.9414015,0.001436328,0.0009125258,0.0003978499,0.000293365,0.0009124579,0.00002792401,0.0003124876],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01444296,"threshold_uncertainty_score":0.06173766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2229243407700816,"score_gpt":0.4885819503792066,"score_spread":0.265657609609125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}