{"id":"W2106627064","doi":"10.1101/gad.623011","title":"Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; National Institute of Allergy and Infectious Diseases; Medical Research Council; Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Institut de Veille Sanitaire; Leukemia and Lymphoma Society; National Institute for Health and Care Research; University College Dublin; National Institutes of Health; Cancer Research UK; Leukemia and Lymphoma Research","keywords":"Biology; GTPase; Elongation factor; Ribosome; Eukaryotic initiation factor; GTP'; Eukaryotic Small Ribosomal Subunit; Biochemistry; Cell biology; Initiation factor; Gene; RNA; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008344519,0.0001994408,0.0001813907,0.00003841518,0.0001176428,0.000009887844,0.0002205867,0.0000979445,0.0001182781],"category_scores_gemma":[0.00001461278,0.0001424019,0.00008478396,0.00008281698,0.00005248628,0.000003021458,0.0001202308,0.0000485221,0.00005264183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001485697,"about_ca_system_score_gemma":0.00009907765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001935085,"about_ca_topic_score_gemma":0.0001494153,"domain_scores_codex":[0.9989836,0.00002742186,0.0002538339,0.0003436763,0.0001667177,0.0002248133],"domain_scores_gemma":[0.9993546,0.00001546959,0.0001082939,0.0004092102,0.00004280695,0.00006960855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001042365,0.004884326,0.445508,0.0001317347,0.009211952,0.0002798536,0.006106473,0.000454802,0.4195711,0.0007174058,0.003478273,0.1086137],"study_design_scores_gemma":[0.0007147983,0.0002206258,0.07018131,0.00003597348,0.000114644,0.000007368874,0.0002319156,0.00001116098,0.920262,0.0003692345,0.007535088,0.0003158302],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961364,0.002780346,0.00006077774,0.00004768154,0.0001275002,0.0001709944,0.00002513936,0.00001061574,0.0006405941],"genre_scores_gemma":[0.9974436,0.0004119563,0.001462972,0.0002009231,0.00003261723,0.00006316053,0.0001393755,0.000023112,0.0002222407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.500691,"threshold_uncertainty_score":0.580698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202431409779102,"score_gpt":0.2099627473758748,"score_spread":0.1897196063979646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}