{"id":"W2106627064","doi":"10.1101/gad.623011","title":"Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome","year":2011,"lang":"en","type":"article","venue":"Genes & Development","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; National Institute of Allergy and Infectious Diseases; Medical Research Council; Institut National de la Santé et de la Recherche Médicale; Canadian Institutes of Health Research; Institut de Veille Sanitaire; Leukemia and Lymphoma Society; National Institute for Health and Care Research; University College Dublin; National Institutes of Health; Cancer Research UK; Leukemia and Lymphoma Research","keywords":"Biology; GTPase; Elongation factor; Ribosome; Eukaryotic initiation factor; GTP'; Eukaryotic Small Ribosomal Subunit; Biochemistry; Cell biology; Initiation factor; Gene; RNA; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009176662,0.0007104232,0.0002756203,0.0005480617,0.0002227597,0.0001222768,0.0002622306,0.0006550739,0.001013619],"category_scores_gemma":[0.0003072063,0.0001924689,0.0001984366,0.0002863003,0.0005827183,0.000126003,0.0003650852,0.0005753305,0.0001761387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002971763,"about_ca_system_score_gemma":0.0002200627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005991,"about_ca_topic_score_gemma":0.001345771,"domain_scores_codex":[0.9998387,0.00002886554,0.0000184094,0.0000430044,0.00004945223,0.0000215936],"domain_scores_gemma":[0.9997792,0.00007352151,0.00006706081,0.000009433612,0.000007355794,0.00006334415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008115991,0.000154537,0.01120544,0.0002304377,0.00014501,0.08596034,0.0002103025,0.001017512,0.8724461,0.002491262,0.00120792,0.02411949],"study_design_scores_gemma":[0.0004804694,0.001651112,0.1422889,0.00007597992,0.0003342109,0.2474385,0.0003252177,0.005914939,0.5767342,0.002360994,0.02229599,0.00009943957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944602,0.0008606933,0.002777789,0.0002859518,0.00005147082,0.00002396031,0.0002993596,0.0002056192,0.001034909],"genre_scores_gemma":[0.9971132,0.0005463195,0.001250892,0.0001059831,0.00001845079,0.0000168865,0.0001514526,0.00002175324,0.000774967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013619,"threshold_uncertainty_score":0.003390849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0202431409779102,"score_gpt":0.2099627473758748,"score_spread":0.1897196063979646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}