{"id":"W2106671241","doi":"10.1158/0008-5472.can-12-0103","title":"MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Fred Hutchinson Cancer Research Center; Howard Hughes Medical Institute","keywords":"RAD51; Cisplatin; DNA damage; DNA repair; PARP inhibitor; Cancer research; Homologous recombination; Poly ADP ribose polymerase; Molecular biology; Biology; DNA; Genome instability; Cancer cell; Cancer; Chemistry; Polymerase; Genetics; Chemotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125348,0.0001096157,0.0001148246,0.00007365034,0.0001168378,0.00003921376,0.00004599946,0.000109336,0.00001800758],"category_scores_gemma":[0.0001411226,0.0001055755,0.00002014485,0.0001506838,0.00006897661,0.00000856605,0.000317234,0.0001184143,0.00001749926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003808895,"about_ca_system_score_gemma":0.00004179093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009362758,"about_ca_topic_score_gemma":0.00008614682,"domain_scores_codex":[0.9986936,0.0001680966,0.0001007691,0.0003624736,0.0002183922,0.0004565966],"domain_scores_gemma":[0.9992472,0.00001812915,0.00001726636,0.0002602238,0.0001234777,0.0003337058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009145947,0.00002144591,0.0008045132,0.00003913249,0.00001146221,0.000005741304,0.0002255657,0.000002461089,0.991427,0.00007244469,0.001640406,0.00565839],"study_design_scores_gemma":[0.0001998559,0.0002319222,0.00311247,0.00004936681,0.000004843653,0.0000144814,0.00005308957,0.00001838803,0.9760216,0.00008022296,0.0200781,0.0001356901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996944,0.0009562593,0.0002844993,0.001033467,0.00005592453,0.0005402986,0.00002071435,0.0000113238,0.0001535482],"genre_scores_gemma":[0.9973946,0.00008892876,0.001230292,0.0001668329,0.0002638342,0.00009960669,0.00002057473,0.00002212972,0.000713266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0184377,"threshold_uncertainty_score":0.4305242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03314217075410196,"score_gpt":0.3418350767209125,"score_spread":0.3086929059668105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}