{"id":"W2106673894","doi":"10.1007/s00280-004-0914-y","title":"Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin","year":2005,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Institut National de la Santé et de la Recherche Médicale","keywords":"Rhodamine 123; P-glycoprotein; Vinca; Vinblastine; Pharmacology; ATP-binding cassette transporter; Multiple drug resistance; Cell culture; Cytotoxicity; Verapamil; In vitro; Biology; Vinca alkaloid; Umbelliferone; Doxorubicin; Chemistry; Vincristine; Biochemistry; Transporter; Coumarin; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002189405,0.0002452027,0.0003656015,0.0002240991,0.0002281085,0.0003197823,0.0004175434,0.0002951875,0.001243072],"category_scores_gemma":[0.0003598694,0.0001600657,0.0001526504,0.0002430055,0.0003506286,0.0002289688,0.0002323649,0.000804013,0.0002243391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006533786,"about_ca_system_score_gemma":0.000674346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003000163,"about_ca_topic_score_gemma":0.002629567,"domain_scores_codex":[0.9998404,0.00004198449,0.00001027775,0.00001241694,0.00002657638,0.00006832273],"domain_scores_gemma":[0.9998713,0.00004033346,0.00002033435,0.00002723732,0.0000121532,0.00002861407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002598581,0.0003957686,0.0005879437,0.00008255486,0.00001705335,0.0004161365,0.00008857299,0.000732693,0.9823287,0.001870138,0.0004106546,0.0104711],"study_design_scores_gemma":[0.0002569513,0.001038599,0.004043691,0.000006459095,0.00001242282,0.0004940977,0.00003105514,0.001701097,0.989513,0.0001595132,0.002735183,0.000008087741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953628,0.0005116844,0.0007210702,0.0001440468,0.00002184295,0.00004256705,0.0001255229,0.00005864278,0.003011859],"genre_scores_gemma":[0.9974307,0.0002577116,0.000494097,0.00002662082,0.000005821088,0.00001903281,0.0002066683,0.0000109068,0.001548402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003000163,"threshold_uncertainty_score":0.005965412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007670302057908099,"score_gpt":0.2630383083437881,"score_spread":0.25536800628588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}