{"id":"W2106702382","doi":"10.1194/jlr.m023218","title":"Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH","year":2012,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Jenny ja Antti Wihurin Rahasto","keywords":"Chemistry; Sphingomyelin; Apolipoprotein B; Biophysics; Extracellular; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815512,0.0001895498,0.0001843084,0.00007437848,0.000118847,0.0001911655,0.0001173141,0.000290201,0.0005374152],"category_scores_gemma":[0.0001849259,0.0001217808,0.0001741297,0.00006983327,0.0001900964,0.0002120628,0.0001383968,0.0004550155,0.0001888855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001114631,"about_ca_system_score_gemma":0.0000589082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002611452,"about_ca_topic_score_gemma":0.0002764498,"domain_scores_codex":[0.9999063,0.000022854,0.000007869139,0.00001484389,0.00002838847,0.00001979553],"domain_scores_gemma":[0.9998904,0.00002798046,0.00003324005,0.000009895043,0.0000164265,0.00002195416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007473723,0.000009910742,0.0002239408,0.00001418842,0.000005418037,0.00005678766,0.00001670844,0.00002049371,0.9992996,0.00001579388,0.000006727716,0.0002557084],"study_design_scores_gemma":[0.00001277236,0.0002874603,0.01278282,0.000005936109,0.0000166944,0.0003436463,0.00004200832,0.0008090362,0.9849827,0.00006733428,0.0006433774,0.000006187831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976236,0.0008972914,0.00103969,0.00004355049,0.000009746561,0.00001047714,0.00003883014,0.00001063766,0.0003260853],"genre_scores_gemma":[0.9984869,0.000347259,0.0006550206,0.0000403082,0.000005370057,0.000009756744,0.00007944385,0.000004647601,0.0003713573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005374152,"threshold_uncertainty_score":0.001797855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07760360273603203,"score_gpt":0.3817212033836128,"score_spread":0.3041176006475808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}