{"id":"W2106729672","doi":"10.1039/c4tb00629a","title":"In vitro and in vivo therapeutic siRNA delivery induced by a tryptophan-rich endosomolytic peptide","year":2014,"lang":"en","type":"article","venue":"Journal of Materials Chemistry B","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Small interfering RNA; Gene knockdown; In vivo; Transfection; Peptide; RNA interference; In vitro; Gene silencing; Biology; Cell biology; Cytotoxicity; Endosome; RNA; Chemistry; Gene; Intracellular; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002848597,0.0004116991,0.0002099147,0.0002118983,0.0001702694,0.0001871607,0.0001506885,0.0002938358,0.0009981318],"category_scores_gemma":[0.0001559299,0.0001644107,0.0002287212,0.000113883,0.000225669,0.0001486812,0.0001087526,0.0004384519,0.0003145633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002553582,"about_ca_system_score_gemma":0.0002449857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006088185,"about_ca_topic_score_gemma":0.0004935201,"domain_scores_codex":[0.9998492,0.00004441524,0.00001350954,0.00003038125,0.00003199247,0.00003059729],"domain_scores_gemma":[0.9998813,0.00003609509,0.00003142744,0.00001415196,0.00001690837,0.00002003523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007414954,0.00003910157,0.00001952268,0.00002024014,0.000002256245,0.00001756734,0.00001044092,0.00006517597,0.9992083,0.00006113071,0.00002490686,0.0004572063],"study_design_scores_gemma":[0.000008514335,0.0003189698,0.0002093374,0.000001122831,0.000005920575,0.00003891871,0.000002564926,0.0003345662,0.9986964,0.000009725744,0.0003725664,0.000001403318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988598,0.001440337,0.007095735,0.00009405652,0.00004590572,0.00005881115,0.0003089544,0.000105539,0.002252662],"genre_scores_gemma":[0.9905813,0.001015379,0.004847182,0.00005157995,0.00001374391,0.00009209337,0.0005373688,0.00003492535,0.002826507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009981318,"threshold_uncertainty_score":0.003339112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008401525825054873,"score_gpt":0.2303743776975035,"score_spread":0.2219728518724486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}