{"id":"W2106771830","doi":"10.1158/0008-5472.can-05-0425","title":"Akt-Mediated Cisplatin Resistance in Ovarian Cancer: Modulation of p53 Action on Caspase-Dependent Mitochondrial Death Pathway","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Protein kinase B; Cytochrome c; Apoptosis; Cancer research; Cisplatin; Mitochondrion; Caspase; Biology; XIAP; Cancer cell; Intrinsic apoptosis; Cell biology; Programmed cell death; Chemistry; Cancer; Biochemistry; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003498744,0.0001255091,0.0001486999,0.0001806668,0.00009595932,0.00002020197,0.0001283013,0.0002198417,0.00007206837],"category_scores_gemma":[0.00005030436,0.0001206006,0.00005047786,0.0002748144,0.00004897875,0.000008100619,0.00004524231,0.0001970112,0.000004294398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095512,"about_ca_system_score_gemma":0.0002519085,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004694452,"about_ca_topic_score_gemma":0.0204851,"domain_scores_codex":[0.9983389,0.0001668532,0.0002813308,0.0004151666,0.000477324,0.000320398],"domain_scores_gemma":[0.9992962,0.00003173216,0.0001018819,0.000292725,0.0002229236,0.0000545058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007194109,0.00007807474,0.001056481,0.00004159523,0.00001188422,0.000005762865,0.0000342806,0.005440689,0.9891276,0.0007755627,0.0006418484,0.002066765],"study_design_scores_gemma":[0.001522916,0.0001800756,0.02926431,0.000103391,0.000005316311,8.51568e-7,0.00003168218,0.0005378795,0.9627873,0.0008912238,0.004505266,0.0001697309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963924,0.0008961547,0.0007240198,0.0002353444,0.0003519474,0.0004715653,0.00008486608,0.000008164849,0.0008355358],"genre_scores_gemma":[0.9957801,0.0003845198,0.0001695444,0.00001368655,0.0006793951,0.0001787243,0.0002215467,0.00002671503,0.002545841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02820783,"threshold_uncertainty_score":0.9973885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04380360503577525,"score_gpt":0.3462940109943216,"score_spread":0.3024904059585463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}