{"id":"W2106779017","doi":"10.1038/ng.717","title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci","year":2010,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2581,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute; Hospital for Sick Children; University of Toronto; SickKids Foundation; Mount Sinai Hospital; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Health and Medical Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; National Institutes of Health; Exzellenzclusters Entzündungsforschung; Fonds De La Recherche Scientifique - FNRS; Cedars-Sinai Medical Center; Deutsche Forschungsgemeinschaft; King's College London; National Institute for Health and Care Research; Action Medical Research; National Center for Research Resources; Fonds Wetenschappelijk Onderzoek; Crohn's and Colitis Foundation; Wellcome Trust; Abbott Laboratories; Crohn's and Colitis Foundation of America","keywords":"Biology; Genome-wide association study; Genetics; Genome; In silico; Genetic association; Disease; Gene; Crohn's disease; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005081686,0.00173394,0.005765055,0.001572875,0.0001650765,0.001376327,0.001323998,0.001629252,0.003032387],"category_scores_gemma":[0.008341243,0.0005360352,0.004140066,0.002520003,0.0003893501,0.0006787216,0.000864635,0.001439101,0.0005380497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005964658,"about_ca_system_score_gemma":0.001230461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001641851,"about_ca_topic_score_gemma":0.004743311,"domain_scores_codex":[0.9983523,0.0006684563,0.0001848003,0.0004047589,0.0003279348,0.00006175324],"domain_scores_gemma":[0.9927846,0.005874925,0.0004629724,0.0002548948,0.0005059821,0.0001166164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002312755,0.00006158678,0.02413841,0.04914102,0.06329796,0.00134852,0.00009687944,0.001455324,0.002721369,0.001671693,0.03614528,0.8176092],"study_design_scores_gemma":[0.002806081,0.001128674,0.1692871,0.02846534,0.3311873,0.01022232,0.0002569775,0.001718452,0.003643468,0.0126529,0.4382774,0.0003538971],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001273066,0.9960855,0.0007151837,0.000956609,0.0002660753,0.00000562059,0.0002273598,0.00002110723,0.0004494907],"genre_scores_gemma":[0.02570191,0.9678836,0.001951932,0.002063284,0.001132128,0.00002775525,0.0007800307,0.00002542502,0.0004338112],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005765055,"threshold_uncertainty_score":0.02687484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02281885005735509,"score_gpt":0.3255244616539011,"score_spread":0.302705611596546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}