{"id":"W2106807427","doi":"10.1242/dmm.007419","title":"A <i>Drosophila</i> model for the Zellweger spectrum of peroxisome biogenesis disorders","year":2011,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Zellweger syndrome; Peroxisome; Biology; Peroxisomal disorder; Biogenesis; Cell biology; Lipid metabolism; Mutation; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002711986,0.001808103,0.000507858,0.001508518,0.001129027,0.0005405904,0.001051867,0.001075285,0.008178312],"category_scores_gemma":[0.0001049109,0.0003527132,0.0006244527,0.0007211188,0.0006334984,0.0004488799,0.0006023791,0.001649459,0.003411563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001003072,"about_ca_system_score_gemma":0.0004727688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002975946,"about_ca_topic_score_gemma":0.004858273,"domain_scores_codex":[0.999616,0.00006683008,0.00005856465,0.0001198601,0.0000900446,0.00004868408],"domain_scores_gemma":[0.9998395,0.00001960642,0.00005330412,0.00002255289,0.0000171609,0.00004778606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003919566,0.0001724039,0.000514117,0.0001755521,0.00003070155,0.0006617892,0.00007851213,0.0002314024,0.9859114,0.003806063,0.003580391,0.004445836],"study_design_scores_gemma":[0.0005987982,0.001782574,0.02181346,0.000245973,0.0002454411,0.007586096,0.0003319811,0.006026225,0.6835756,0.002126674,0.27553,0.0001372475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.826836,0.009045,0.05030463,0.00326199,0.001002175,0.002919497,0.05614816,0.003888921,0.04659364],"genre_scores_gemma":[0.7136073,0.008352658,0.1115405,0.001828358,0.0001261498,0.003777555,0.05137056,0.0009470051,0.1084499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008178312,"threshold_uncertainty_score":0.02735925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776042658197238,"score_gpt":0.2256541150251922,"score_spread":0.1978936884432198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}