{"id":"W2106837071","doi":"10.1038/sj.bjp.0703784","title":"Vasoconstrictor actions of isoprostanes <i>via</i> tyrosine kinase and Rho kinase in human and canine pulmonary vascular smooth muscles","year":2001,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"","keywords":"Chelerythrine; Endocrinology; Rho-associated protein kinase; Internal medicine; Vasoconstriction; Pulmonary artery; Hypoxic pulmonary vasoconstriction; Medicine; Chemistry; Tyrosine kinase; Prostaglandin; Protein kinase C; Calphostin C; Pharmacology; Receptor; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268691,0.0001286887,0.000486265,0.0002513489,0.000101325,0.00001348648,0.00006148043,0.00009350199,0.0002218649],"category_scores_gemma":[0.00004903307,0.0001413,0.00008295265,0.0002299283,0.000376796,0.0002357587,0.00004508144,0.0004147161,2.792053e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004125772,"about_ca_system_score_gemma":0.00007141734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005486615,"about_ca_topic_score_gemma":0.0002140408,"domain_scores_codex":[0.9988994,0.0001300289,0.0004333823,0.0001656399,0.0001589725,0.0002125938],"domain_scores_gemma":[0.9992332,0.0001084408,0.0002812805,0.00004508199,0.0001825998,0.0001493779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003047309,0.000883514,0.05264463,0.0001476204,0.000147211,0.007590514,0.00009180557,0.00000691022,0.8922481,0.00002334234,0.0006033561,0.04530831],"study_design_scores_gemma":[0.01031579,0.001198087,0.8461515,0.0008456131,0.0007365666,0.02786615,0.0005653747,0.0001253409,0.1052567,0.0001575162,0.006473401,0.0003079447],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882157,0.01055542,0.0001081467,0.0005235755,0.00013129,0.000211133,0.00003144968,0.000007554929,0.0002157718],"genre_scores_gemma":[0.9871861,0.01213956,0.0001819142,0.00018335,0.0002218129,0.000004269181,0.000006274756,0.00001443455,0.00006228325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7935069,"threshold_uncertainty_score":0.5762048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845940648804265,"score_gpt":0.2947497103185598,"score_spread":0.2762903038305171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}