{"id":"W2106840257","doi":"10.1210/jc.2014-1223","title":"Effects of Recombinant Activins on Steroidogenesis in Human Granulosa-Lutein Cells","year":2014,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Aromatase; Internal medicine; Endocrinology; Activin receptor; Biology; Steroidogenic acute regulatory protein; Progesterone receptor; Granulosa cell; Receptor; Western blot; Activin type 2 receptors; Ovary; Messenger RNA; Estrogen receptor; Transforming growth factor; TGF beta signaling pathway; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003185582,0.0002876082,0.0002129779,0.0002081056,0.0001367162,0.0003598913,0.00009937024,0.0001346305,0.001074357],"category_scores_gemma":[0.0002873898,0.00008124382,0.0002042117,0.0002300011,0.0002735378,0.0001186338,0.0001399595,0.0003602214,0.000386518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762843,"about_ca_system_score_gemma":0.0002101885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006192441,"about_ca_topic_score_gemma":0.000571392,"domain_scores_codex":[0.9998172,0.0000545136,0.00002992031,0.00002588365,0.00003956569,0.00003300063],"domain_scores_gemma":[0.9998097,0.00008837857,0.00002965414,0.00003253462,0.00001802984,0.00002177665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001463437,0.00018803,0.0008647906,0.0001243412,0.00001561769,0.0001328311,0.00006325821,0.0001551779,0.9921941,0.00006249464,0.00009494895,0.004641022],"study_design_scores_gemma":[0.0002772189,0.002163336,0.007671506,0.00001859663,0.00006665345,0.0003611343,0.0001027201,0.000718352,0.9840424,0.0000417462,0.004531695,0.000004692025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939018,0.003319019,0.0007293691,0.00009437285,0.00004153172,0.00005602711,0.0002933109,0.00003058198,0.001533956],"genre_scores_gemma":[0.9953927,0.001337131,0.00137866,0.00006473412,0.00002648085,0.00004602172,0.0009027483,0.000007826911,0.0008438506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001074357,"threshold_uncertainty_score":0.003594041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01785327277952386,"score_gpt":0.3278891613170832,"score_spread":0.3100358885375593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}