{"id":"W2106855445","doi":"10.1016/j.cell.2014.01.026","title":"NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":700,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Goblet cell; Biology; Mucus; Secretion; Cell biology; Inflammasome; Innate immune system; Microbiology; Immune system; Immunology; Inflammation; Epithelium; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000298036,0.0001721428,0.0001313789,0.0000169666,0.0001681485,0.00005155127,0.0002495793,0.0002038288,0.00004330953],"category_scores_gemma":[0.00002262678,0.0001386803,0.00006674132,0.00006321384,0.00009647483,0.000004093029,0.000114598,0.000185634,0.00007908254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002430774,"about_ca_system_score_gemma":0.0000782272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004320181,"about_ca_topic_score_gemma":0.00004614355,"domain_scores_codex":[0.9989215,0.0001290854,0.0002234942,0.0003232456,0.00006138444,0.0003413614],"domain_scores_gemma":[0.9993535,0.00002629905,0.0001368449,0.0003551133,0.00005324442,0.00007503259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002932148,0.00003175075,0.0001912736,0.00004923869,0.000005494757,2.32549e-7,0.0001568296,0.00003504946,0.9826126,0.00001044307,0.01673362,0.0001442127],"study_design_scores_gemma":[0.0004658818,0.0002313688,0.0005036135,0.00001198722,0.00001230228,0.00000558132,0.00009112159,0.0001310677,0.8441871,0.00001552969,0.154181,0.0001635007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995059,0.0007404033,0.0006082238,0.0005104314,0.0001831172,0.000223176,0.00001878267,0.00001895649,0.002637919],"genre_scores_gemma":[0.9952564,0.0001111537,0.0001968384,0.0004159554,0.0002119248,0.000008451757,0.0001869146,0.00002797974,0.003584408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1384255,"threshold_uncertainty_score":0.565522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005179414755000696,"score_gpt":0.2195016186949359,"score_spread":0.2143222039399352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}