{"id":"W2106855445","doi":"10.1016/j.cell.2014.01.026","title":"NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":700,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Goblet cell; Biology; Mucus; Secretion; Cell biology; Inflammasome; Innate immune system; Microbiology; Immune system; Immunology; Inflammation; Epithelium; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003787209,0.000407382,0.0004635339,0.0004384966,0.0002862241,0.001036685,0.0002837475,0.000727835,0.001691627],"category_scores_gemma":[0.0003674988,0.0002065313,0.0003414467,0.0001923624,0.000603217,0.001058377,0.000808134,0.0008733452,0.0008029462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003589877,"about_ca_system_score_gemma":0.0003132107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002068865,"about_ca_topic_score_gemma":0.0003325545,"domain_scores_codex":[0.9995356,0.0001100283,0.00003511411,0.0000919326,0.0001200237,0.0001074021],"domain_scores_gemma":[0.9997113,0.00001667133,0.00007701849,0.00002082523,0.00005147044,0.0001226519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000763096,0.00002717986,0.002023468,0.0001263169,0.00001216839,0.000379194,0.00008496385,0.0001088113,0.9907058,0.0008359174,0.0002927661,0.004640404],"study_design_scores_gemma":[0.0002070662,0.001445021,0.1146057,0.0001479968,0.00008824283,0.003540698,0.001172032,0.006628999,0.8473842,0.004513573,0.02019475,0.00007167143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599192,0.01793949,0.0128069,0.001978967,0.0002861976,0.00005940354,0.0008304836,0.0003596666,0.005819757],"genre_scores_gemma":[0.9889114,0.002998352,0.003538428,0.0002536966,0.00008994303,0.00002579547,0.0003205906,0.00004128052,0.003820487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691627,"threshold_uncertainty_score":0.005659103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005179414755000696,"score_gpt":0.2195016186949359,"score_spread":0.2143222039399352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}