{"id":"W2106859063","doi":"10.1107/s0907444913002576","title":"The structure of the SBP-Tag–streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits","year":2013,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Research Council Canada; National Center for Research Resources; National Institute of General Medical Sciences; Western Economic Diversification Canada; Canadian Institutes of Health Research; University of Saskatchewan","keywords":"Bridging (networking); Streptavidin; Scaffold; Scaffold protein; Biophysics; Computational biology; Crystallography; Chemistry; Nanotechnology; Computer science; Materials science; Biology; Biochemistry; Biotin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023292,0.0003262423,0.0004452462,0.0001365328,0.0002396972,0.0005284494,0.0003952442,0.0005036917,0.00191981],"category_scores_gemma":[0.0002703023,0.0002991573,0.000274784,0.0001988745,0.0002760344,0.0002479313,0.0002269068,0.0007329569,0.0008318591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007163382,"about_ca_system_score_gemma":0.0003925302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001514507,"about_ca_topic_score_gemma":0.001340776,"domain_scores_codex":[0.9999006,0.00001165479,0.000005954929,0.0000269737,0.00003277645,0.00002201852],"domain_scores_gemma":[0.9998347,0.00003351844,0.00002807411,0.00001460276,0.00002059002,0.00006848529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005074773,0.00009386178,0.002646426,0.0001417745,0.00003876901,0.001092424,0.0001718689,0.001421175,0.9880624,0.00081563,0.0006435881,0.004364767],"study_design_scores_gemma":[0.0002998354,0.0008478546,0.08529326,0.00004849352,0.0001055824,0.003520482,0.0005041001,0.05893731,0.8282853,0.001695822,0.02036596,0.00009605142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929034,0.0004620471,0.004615259,0.0001573623,0.00003205572,0.00001648445,0.0003068548,0.0002161148,0.001290408],"genre_scores_gemma":[0.9929965,0.0001710308,0.00387428,0.00009133509,0.000007953389,0.00001223121,0.001021139,0.00002548966,0.001800176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00191981,"threshold_uncertainty_score":0.0064224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01886345556755168,"score_gpt":0.2377369535658903,"score_spread":0.2188734979983386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}