{"id":"W2106880687","doi":"10.4049/jimmunol.181.7.4852","title":"T Cell-Dendritic Cell Immunological Synapses Contain TCR-dependent CD28-CD80 Clusters That Recruit Protein Kinase Cθ","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; York University; Leukemia and Lymphoma Society","keywords":"CD80; T-cell receptor; CD28; Immunological synapse; T cell; Cell biology; Biology; CD86; Dendritic cell; Chemistry; Cytotoxic T cell; Molecular biology; Antigen; Immunology; Biochemistry; Immune system; In vitro; CD40","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001507736,0.0007584434,0.001439317,0.0004902913,0.001070235,0.0000327481,0.002264295,0.001213861,0.001615835],"category_scores_gemma":[0.0002624743,0.0005074273,0.0005629346,0.000320459,0.00268787,0.0003118833,0.0006698429,0.003136057,0.001483132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280381,"about_ca_system_score_gemma":0.000407085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002502167,"about_ca_topic_score_gemma":0.00002019398,"domain_scores_codex":[0.9931421,0.003034863,0.00161648,0.0005189094,0.0002088482,0.001478859],"domain_scores_gemma":[0.9958466,0.001000011,0.001553006,0.001098742,0.0004222554,0.00007933258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003202756,0.001009058,0.0003886817,0.00003229565,0.0007661511,0.0006495007,0.001502737,0.00002474367,0.9876796,0.0001824876,0.003160574,0.001401435],"study_design_scores_gemma":[0.00797622,0.004193163,0.001301554,0.0001135531,0.0003268092,0.01688026,0.004273548,0.000002691379,0.9420977,0.0003929127,0.02176714,0.0006744244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9191253,0.07342351,0.0003554092,0.001664177,0.002646886,0.000773631,0.00002158075,0.0001098929,0.001879679],"genre_scores_gemma":[0.9789991,0.007440835,0.0001418012,0.0004781318,0.0001147876,0.00004234963,0.00002819972,0.00007360649,0.01268117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06598268,"threshold_uncertainty_score":0.9997377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424450263076058,"score_gpt":0.2257874554132601,"score_spread":0.2015429527824996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}