{"id":"W2106883129","doi":"10.1158/1055-9965.epi-12-1037","title":"Single-Nucleotide Polymorphisms in <i>Aldo-Keto</i> and <i>Carbonyl Reductase</i> Genes Are Not Associated with Acute Cardiotoxicity after Daunorubicin Chemotherapy","year":2012,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Cardiotoxicity; Anthracycline; Daunorubicin; Single-nucleotide polymorphism; Pharmacogenetics; Myeloid leukemia; Pharmacology; Medicine; Cancer research; Leukemia; Biology; Internal medicine; Oncology; Chemotherapy; Breast cancer; Cancer; Genetics; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004271317,0.0001495726,0.0002540752,0.0002539936,0.000160702,0.0002281733,0.0001352631,0.0001838407,0.001181698],"category_scores_gemma":[0.001051464,0.00007154717,0.0002689453,0.0003632123,0.0002151918,0.00006797031,0.0001070422,0.0002253156,0.0001372233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000159225,"about_ca_system_score_gemma":0.0001545179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007614666,"about_ca_topic_score_gemma":0.001058935,"domain_scores_codex":[0.9996044,0.0001237746,0.00005519233,0.0001152129,0.00006915035,0.0000323068],"domain_scores_gemma":[0.9986812,0.0004122552,0.0005843302,0.0001136807,0.00008907885,0.0001194214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008486472,0.00005797333,0.9764979,0.00002633369,0.000228047,0.0001604947,0.00005257551,0.00027364,0.0185303,0.00005173381,0.00006084725,0.003211472],"study_design_scores_gemma":[0.00001812111,0.0002546124,0.9956297,0.000003914796,0.0001192515,0.0004494736,0.00002335846,0.000368433,0.00287824,0.00005402618,0.0001978017,0.000002980311],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994227,0.0001094762,0.0001870728,0.00001268562,0.000002318726,0.00000385011,0.0001089136,0.000002891552,0.0001502652],"genre_scores_gemma":[0.9997253,0.00002010475,0.00010209,0.00000770925,0.000002564806,0.000002465099,0.00009398008,0.000001378355,0.00004436592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001181698,"threshold_uncertainty_score":0.003953159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0341524919937571,"score_gpt":0.3028768467119775,"score_spread":0.2687243547182204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}