{"id":"W2106885160","doi":"10.2337/db06-0734","title":"Human Islet Amyloid Polypeptide Oligomers Disrupt Cell Coupling, Induce Apoptosis, and Impair Insulin Secretion in Isolated Human Islets","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"","keywords":"Islet; Endocrinology; Insulin; Internal medicine; Secretion; Amyloid (mycology); Insulin oscillation; Transplantation; Extracellular; Biology; Chemistry; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002723691,0.0003150957,0.0005267627,0.0003721663,0.0001767757,0.00005551922,0.00008316542,0.0001918013,0.0001991159],"category_scores_gemma":[0.00005588504,0.0003010033,0.00009195723,0.0004040964,0.0001483966,0.0001470984,0.00005014218,0.0003356577,0.00004920921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008813071,"about_ca_system_score_gemma":0.00003546899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005902703,"about_ca_topic_score_gemma":0.00001302478,"domain_scores_codex":[0.998195,0.00004538121,0.0005100794,0.0004524907,0.0002471029,0.0005499281],"domain_scores_gemma":[0.9992076,0.00007948758,0.0001576085,0.0003037828,0.00006894141,0.0001825413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001632239,0.0002469053,0.288874,0.0001204408,0.0000242657,0.00000343412,0.0001290613,0.00002240764,0.7094007,0.00008714222,0.0009957843,0.00007955122],"study_design_scores_gemma":[0.005197165,0.0007019799,0.3846596,0.0003605481,0.0001637554,0.000002344056,0.0003461579,0.002986492,0.6036733,0.0004988869,0.0008213277,0.0005883964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932029,0.001025261,0.000005877656,0.0002136142,0.0001037911,0.0003989257,0.00001921179,0.0001775265,0.00485295],"genre_scores_gemma":[0.9977739,0.00002670533,0.00007002603,0.0005598736,0.0002110409,0.00004693701,0.0003729046,0.00005007234,0.0008885427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1057273,"threshold_uncertainty_score":0.9999442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00838872520717806,"score_gpt":0.2414876415138924,"score_spread":0.2330989163067144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}