{"id":"W2106885160","doi":"10.2337/db06-0734","title":"Human Islet Amyloid Polypeptide Oligomers Disrupt Cell Coupling, Induce Apoptosis, and Impair Insulin Secretion in Isolated Human Islets","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":193,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"","keywords":"Islet; Endocrinology; Insulin; Internal medicine; Secretion; Amyloid (mycology); Insulin oscillation; Transplantation; Extracellular; Biology; Chemistry; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247594,0.0001943736,0.0001811008,0.0001072182,0.00008833256,0.0002489041,0.00007876199,0.0001595205,0.0005890146],"category_scores_gemma":[0.0001697309,0.0001214059,0.0001937279,0.00009650925,0.0001246679,0.0001527539,0.0001564735,0.0003822256,0.0001759766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001208809,"about_ca_system_score_gemma":0.00007963192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001948514,"about_ca_topic_score_gemma":0.0002065518,"domain_scores_codex":[0.9998749,0.00003309403,0.00001256024,0.00002289604,0.00003077381,0.00002574158],"domain_scores_gemma":[0.9999127,0.00002633769,0.00001602181,0.00001658508,0.000006242597,0.00002213001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002762351,0.00009439601,0.0005716354,0.00002477845,0.00001507455,0.0001185305,0.00004307355,0.00008695522,0.9972377,0.00003933676,0.00002600725,0.001466175],"study_design_scores_gemma":[0.00009515202,0.002662347,0.0138951,0.00001050365,0.00004986168,0.0006867981,0.00007824014,0.001627123,0.9795104,0.000113685,0.001265383,0.000005386211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983012,0.0006472057,0.0005866999,0.00001686892,0.00001210973,0.000011226,0.00004011408,0.00001053442,0.0003740208],"genre_scores_gemma":[0.9984578,0.0004897762,0.0005172419,0.00003040101,0.000005337734,0.00001130371,0.0001126178,0.000006501522,0.0003689758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005890146,"threshold_uncertainty_score":0.00197047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00838872520717806,"score_gpt":0.2414876415138924,"score_spread":0.2330989163067144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}