{"id":"W2106885643","doi":"10.1002/anie.201203263","title":"Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**","year":2012,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1221,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Encana (Canada)","funders":"Canadian Institutes of Health Research","keywords":"Gene silencing; In vivo; Potency; Chemistry; In vitro; Gene delivery; Lipid metabolism; Cationic polymerization; Biochemistry; Transfection; Molecular biology; Gene; Biophysics; Biology; Genetics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171777528078813,"score_gpt":0.2589041256503743,"score_spread":0.241726372842493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."},"direct_labels":[],"classifier":{"requested":true,"available":true,"version":"metacan-v1-d91a1de5be90","frame_rows_covered":4299418,"decision_targets":["metaresearch","metaepi_narrow","metaepi_broad","bibliometrics","sts","scholarly_communication","open_science","research_integrity","randomized_trial","nonrandomized_trial","observational","systematic_review","meta_analysis","case_report","qualitative","simulation_or_modeling","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame.","warning":null},"prediction":{"classifier_version":"metacan-v1-d91a1de5be90","candidate_union":["bench_or_experimental","not_applicable"],"consensus_intersection":["bench_or_experimental"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"scores":{"codex":{"metaresearch":0.000045777065690089265,"metaepi_narrow":0.000015259021896696422,"metaepi_broad":0,"bibliometrics":0.000015259021896696422,"sts":0.000030518043793392844,"scholarly_communication":0.00044251163500419623,"open_science":0.000045777065690089265,"research_integrity":0.000045777065690089265,"randomized_trial":0.00009155413138017853,"nonrandomized_trial":0.000030518043793392844,"observational":0.000686655985351339,"systematic_review":0.000015259021896696422,"meta_analysis":0.000030518043793392844,"case_report":0.00009155413138017853,"qualitative":0.00012207217517357137,"simulation_or_modeling":0.0001373311970702678,"bench_or_experimental":0.998443579766537,"theoretical_or_conceptual":0.000045777065690089265,"not_applicable":0.02038605325398642,"design_other":0.00044251163500419623},"gemma":{"metaresearch":0.00024414435034714275,"metaepi_narrow":0.000015259021896696422,"metaepi_broad":0.000015259021896696422,"bibliometrics":0.000015259021896696422,"sts":0.000030518043793392844,"scholarly_communication":0.000045777065690089265,"open_science":0.000045777065690089265,"research_integrity":0.000045777065690089265,"randomized_trial":0.000030518043793392844,"nonrandomized_trial":0.0004272526131074998,"observational":0.00006103608758678569,"systematic_review":0,"meta_analysis":0.000015259021896696422,"case_report":0.00006103608758678569,"qualitative":0.00012207217517357137,"simulation_or_modeling":0.00044251163500419623,"bench_or_experimental":0.9957732509346151,"theoretical_or_conceptual":0.0002136263065537499,"not_applicable":0.057694361791409174}},"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame."}}