{"id":"W2106898979","doi":"10.1128/cvi.13.4.475-485.2006","title":"High Titers of Circulating Maternal Antibodies Suppress Effector and Memory B-Cell Responses Induced by an Attenuated Rotavirus Priming and Rotavirus-Like Particle-Immunostimulating Complex Boosting Vaccine Regimen","year":2006,"lang":"en","type":"article","venue":"Clinical and Vaccine Immunology","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Ohio State University","keywords":"Priming (agriculture); Immunology; Rotavirus; Virology; Medicine; Regimen; Titer; Antibody; Vaccination; ELISPOT; Immune system; Biology; Virus; T cell; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002828699,0.000349923,0.0002227253,0.0001708114,0.00006305073,0.0001778706,0.000188016,0.000216623,0.0007006263],"category_scores_gemma":[0.0003825093,0.0001691206,0.0001299291,0.00005478631,0.0001922942,0.0001382576,0.0001232724,0.0005747961,0.0002139373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001966861,"about_ca_system_score_gemma":0.0001864827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002761908,"about_ca_topic_score_gemma":0.0003718639,"domain_scores_codex":[0.9998302,0.00004731825,0.000009799994,0.00002561216,0.00003616099,0.00005088091],"domain_scores_gemma":[0.9997411,0.00006127576,0.00008477217,0.00002641028,0.00002079842,0.00006562028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009993142,0.0002675497,0.001457934,0.00003567633,0.00001244392,0.00008737471,0.00003075747,0.00006674094,0.9920267,0.00006267281,0.00004178494,0.004910984],"study_design_scores_gemma":[0.0002770084,0.03037884,0.04280128,0.00003100354,0.00009806671,0.0008587495,0.00007930755,0.001615121,0.9208687,0.0001340958,0.002848991,0.000009006503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988289,0.0002481389,0.0004056187,0.00003019046,0.00001118312,0.00001036748,0.00002838621,0.00002514953,0.0004119648],"genre_scores_gemma":[0.9983985,0.0002027098,0.0006270951,0.00005515767,0.00001539834,0.00002218173,0.00009449743,0.000007266498,0.0005771994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007006263,"threshold_uncertainty_score":0.002343833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05465739143649784,"score_gpt":0.362169078393481,"score_spread":0.3075116869569832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}