{"id":"W2106906679","doi":"10.1128/mcb.00845-10","title":"SCF <sup>Cdc4</sup> Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor","year":2010,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Engineering and Physical Sciences Research Council; Directorate for Biological Sciences; Michael Smith Health Research BC; Wellcome Trust","keywords":"Biology; Cell division control protein 4; Cell biology; Phosphorylation; Ubiquitin ligase; Ubiquitin; Cyclin-dependent kinase 1; Genetics; Cell cycle; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001284371,0.0003149972,0.0001315256,0.0001721342,0.0001459164,0.0003570513,0.0002643391,0.000116496,0.0007333125],"category_scores_gemma":[0.00009546916,0.0001422391,0.0001090849,0.0001503843,0.000188735,0.0001043083,0.0002069413,0.0002757496,0.000353416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345313,"about_ca_system_score_gemma":0.0002073893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007444545,"about_ca_topic_score_gemma":0.001131024,"domain_scores_codex":[0.9998819,0.00002061429,0.00001297667,0.000017958,0.00003702407,0.00002946343],"domain_scores_gemma":[0.9999216,0.00001267236,0.00002904425,0.00001028326,0.000005946484,0.0000203871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009402037,0.00001889561,0.0003327176,0.00002178737,0.00000318149,0.0000720862,0.00000635636,0.0001128888,0.9971643,0.000274824,0.00004097117,0.001857882],"study_design_scores_gemma":[0.000008181022,0.00005234518,0.002126829,0.000002660542,0.000007208278,0.0001968141,0.00001290331,0.001195586,0.9934111,0.00005120893,0.002932778,0.000002309166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960831,0.0006556864,0.001764093,0.00002908164,0.00001207548,0.00001053042,0.0002002552,0.00007153535,0.00117349],"genre_scores_gemma":[0.9960413,0.0004351214,0.001422317,0.00001554676,0.000004237995,0.000009149033,0.0003931736,0.00001940706,0.001659681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007444545,"threshold_uncertainty_score":0.002505481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006489891720227384,"score_gpt":0.2183141432227492,"score_spread":0.2118242515025218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}