{"id":"W2106923566","doi":"10.1128/mcb.06620-11","title":"Regulation of Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase (Btk) through a Novel SH3-Dependent Interaction with Ankyrin Repeat Domain 54 (ANKRD54)","year":2012,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Pharmacyclics","keywords":"Bruton's tyrosine kinase; Ankyrin repeat; LYN; X-linked agammaglobulinemia; SH3 domain; Biology; Tyrosine kinase; Tyrosine; Src family kinase; Cell biology; Kinase; Molecular biology; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008675631,0.0002019177,0.0001253782,0.00007581701,0.0001446528,0.0002348862,0.0001432779,0.0001553635,0.0005563439],"category_scores_gemma":[0.00008982124,0.00007918741,0.0001852572,0.00006563885,0.0002041691,0.0001562931,0.000261022,0.0002421326,0.0002437526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003425974,"about_ca_system_score_gemma":0.0001102845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004498295,"about_ca_topic_score_gemma":0.0006194609,"domain_scores_codex":[0.9999166,0.00001419497,0.000006352821,0.00002243533,0.00002034332,0.0000201127],"domain_scores_gemma":[0.9999515,0.000009615818,0.00002272939,0.000004057132,0.000003508993,0.000008618832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004095522,0.000006006422,0.0001279474,0.00001289429,0.000001872485,0.0000219854,0.000005771749,0.00003265886,0.9993526,0.0000505272,0.00001095332,0.0003357494],"study_design_scores_gemma":[0.00001771259,0.0001106379,0.007486599,0.000003751968,0.0000104323,0.0002954733,0.00002350643,0.001999695,0.988228,0.00005636877,0.001762416,0.000005360063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976307,0.0006444957,0.00126175,0.00003303897,0.000006742402,0.000005239232,0.00005535931,0.00003434844,0.0003282116],"genre_scores_gemma":[0.9981432,0.0003260569,0.0007230841,0.00001329202,0.000002790312,0.000008086905,0.0001113507,0.000008236675,0.0006639261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005563439,"threshold_uncertainty_score":0.002485693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00812817473133107,"score_gpt":0.2193587604055283,"score_spread":0.2112305856741973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}