{"id":"W2106925992","doi":"10.1073/pnas.1315883111","title":"Molecular profiling of <i>Mycobacterium tuberculosis</i> identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Brandeis University","keywords":"Mycobacterium tuberculosis; Mycobacterium bovis; Tuberculosis; Virulence; Microbiology; Mycobacterium; Pathogen; Biology; Virology; Mycobacterium tuberculosis complex; Bacteria; Medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001071647,0.0002866671,0.0002086235,0.0002534266,0.00008390214,0.0002510106,0.0001451755,0.0003093713,0.000471408],"category_scores_gemma":[0.0002041103,0.00009828443,0.0002187078,0.0002566093,0.000136034,0.0001297259,0.0001160637,0.0002720456,0.0004405427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885481,"about_ca_system_score_gemma":0.00008753805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007343951,"about_ca_topic_score_gemma":0.0006943449,"domain_scores_codex":[0.999891,0.00001147067,0.000008412585,0.00002822006,0.00003137265,0.00002943885],"domain_scores_gemma":[0.9998795,0.00001929719,0.00003794093,0.00001465353,0.00002654297,0.00002203476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002764923,0.000003933556,0.0005355328,0.000007940206,0.000001273976,0.00002903103,0.000005282195,0.00001843433,0.9990164,0.00001084532,0.000006436783,0.0003372197],"study_design_scores_gemma":[0.000005984801,0.0002025288,0.02622743,0.000006218,0.00001582961,0.0005236411,0.00005524439,0.0008605503,0.970826,0.00005172067,0.001220376,0.000004495072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996795,0.0003323429,0.001416088,0.0000436935,0.000005086827,0.00001873967,0.0007549125,0.00004621789,0.0005879677],"genre_scores_gemma":[0.9935064,0.0002543657,0.003431647,0.00006131249,0.000005585939,0.00001718662,0.001941252,0.00003299099,0.000749169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007343951,"threshold_uncertainty_score":0.00157702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111658536850261,"score_gpt":0.311409639886521,"score_spread":0.2802930545180184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}