{"id":"W2106986615","doi":"10.1371/journal.pone.0007258","title":"Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale","keywords":"Tyrosine-kinase inhibitor; Tyrosine kinase; Cancer research; Stem cell factor; Imatinib; Biology; Pharmacology; Signal transduction; Cell biology; Cancer; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074911,0.0001468742,0.000259251,0.00006672574,0.000177741,0.00001623828,0.00006676455,0.0001378056,0.0003882099],"category_scores_gemma":[0.00006461025,0.0001375972,0.00003384175,0.00009380234,0.00008026024,0.00005290361,0.00003700912,0.0002416384,0.000179933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002733878,"about_ca_system_score_gemma":0.00001918558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003095744,"about_ca_topic_score_gemma":0.000007324245,"domain_scores_codex":[0.9991362,0.00005571945,0.0001934208,0.0002709939,0.00003932184,0.0003043097],"domain_scores_gemma":[0.9996528,0.00003578853,0.00007218279,0.0001228872,0.00008218581,0.00003418245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347333,0.001004446,0.0006665669,0.00002992276,0.0001003906,0.00001246229,0.000320403,2.733706e-7,0.9928278,0.0004384112,0.002050933,0.00241362],"study_design_scores_gemma":[0.001823312,0.0008889146,0.007081151,0.0001331053,0.0001458485,0.00002423473,0.0001218111,0.00001843474,0.9815638,0.0002413407,0.007655438,0.0003025907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881626,0.004879461,0.00002631193,0.001173077,0.00007505034,0.0002459825,0.00003059013,0.00009033991,0.005316603],"genre_scores_gemma":[0.9932777,0.0001290328,0.0008060577,0.0003545645,0.0001034138,0.000008509707,0.00009120582,0.0000121223,0.005217387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01126402,"threshold_uncertainty_score":0.5611051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439209867116334,"score_gpt":0.1962432202227534,"score_spread":0.1818511215515901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}