{"id":"W2106986615","doi":"10.1371/journal.pone.0007258","title":"Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale","keywords":"Tyrosine-kinase inhibitor; Tyrosine kinase; Cancer research; Stem cell factor; Imatinib; Biology; Pharmacology; Signal transduction; Cell biology; Cancer; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002032659,0.0006757656,0.0004070338,0.0003069329,0.0001514452,0.0003201963,0.000279022,0.0003835711,0.001392503],"category_scores_gemma":[0.0001144622,0.0001194372,0.0002713038,0.0002359522,0.0002135688,0.0002414763,0.0001551802,0.000496179,0.0009978918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004824904,"about_ca_system_score_gemma":0.0003288867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003854539,"about_ca_topic_score_gemma":0.001181113,"domain_scores_codex":[0.9998629,0.0000178245,0.00001428627,0.00002843305,0.00004389211,0.00003263206],"domain_scores_gemma":[0.9999166,0.00001161756,0.00002533958,0.000003817279,0.00001396921,0.00002861226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005476261,0.0001363517,0.0007511125,0.0002103078,0.0000308761,0.0002831485,0.00001560824,0.0005969598,0.9690618,0.0001702051,0.0006901085,0.02750602],"study_design_scores_gemma":[0.0007145003,0.007897601,0.008061279,0.00003015104,0.0001595991,0.006052019,0.00002541224,0.002924128,0.9504657,0.00008915472,0.02354977,0.00003063723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526228,0.0307616,0.007995126,0.0004319322,0.0002008361,0.0002378453,0.0007223235,0.0005247015,0.006502741],"genre_scores_gemma":[0.9796077,0.008640218,0.005192485,0.0001703258,0.0001107778,0.0001220959,0.001864841,0.00002748353,0.004263937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001392503,"threshold_uncertainty_score":0.004658401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01439209867116334,"score_gpt":0.1962432202227534,"score_spread":0.1818511215515901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}