{"id":"W2106999981","doi":"10.1186/ar4614","title":"Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules","year":2014,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Polytechnique Montréal; McGill University; Montreal General Hospital; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mesenchymal stem cell; Rheumatology; Hedgehog; Indian hedgehog; Medicine; Hedgehog signaling pathway; Stem cell; Cell biology; Internal medicine; Signal transduction; Cancer research; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001617848,0.0001966364,0.0003514327,0.0002132447,0.0002239413,0.00002318803,0.0003408288,0.0001843159,0.00003364885],"category_scores_gemma":[0.00006613658,0.0001948271,0.0001503326,0.0002959547,0.0004163733,0.000008792146,0.0001175023,0.0001455501,0.000007558222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001716899,"about_ca_system_score_gemma":0.00007806029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001070815,"about_ca_topic_score_gemma":0.00008324883,"domain_scores_codex":[0.9973144,0.0008006106,0.0003806985,0.0004481984,0.0005847529,0.0004713175],"domain_scores_gemma":[0.9985896,0.0001254598,0.0001581623,0.0005369546,0.0004755908,0.0001141736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009524894,0.00008395449,0.0009723215,0.00006252775,0.00009220328,0.000003114227,0.0004894331,0.0001897481,0.9376606,0.00008377385,0.0001416131,0.06012543],"study_design_scores_gemma":[0.0009605457,0.001837751,0.001167608,0.0001322317,0.000002949175,0.000003513581,0.0001958478,0.00004467049,0.9941068,0.0002608829,0.001108273,0.0001789008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940607,0.004393953,0.000579577,0.00005279972,0.00005606151,0.0004824343,0.00001876939,0.00001376988,0.0003419451],"genre_scores_gemma":[0.998076,0.001090314,0.0003460699,0.00002643657,0.0001727815,0.00005132751,0.00004129728,0.00004664147,0.0001491139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05994652,"threshold_uncertainty_score":0.7944817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421927825731236,"score_gpt":0.3083848925635425,"score_spread":0.2741656143062301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}