{"id":"W2106999981","doi":"10.1186/ar4614","title":"Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules","year":2014,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Polytechnique Montréal; McGill University; Montreal General Hospital; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mesenchymal stem cell; Rheumatology; Hedgehog; Indian hedgehog; Medicine; Hedgehog signaling pathway; Stem cell; Cell biology; Internal medicine; Signal transduction; Cancer research; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008480919,0.0003314868,0.0001773197,0.0002319601,0.000122295,0.0002037486,0.0001624765,0.000196145,0.001962597],"category_scores_gemma":[0.00007193212,0.0000902211,0.0002699778,0.0001211082,0.0002018073,0.0001290363,0.000129508,0.000263224,0.0002656691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001872069,"about_ca_system_score_gemma":0.0001753168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008858235,"about_ca_topic_score_gemma":0.001530689,"domain_scores_codex":[0.9998925,0.00001926728,0.00001266237,0.00001894033,0.00003343511,0.00002312713],"domain_scores_gemma":[0.9999588,0.00001034185,0.00001075906,0.000003885833,0.000006407817,0.000009909697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004304392,0.00006455695,0.0001591428,0.000101239,0.000009625725,0.00008469787,0.00002174549,0.0000476886,0.9966524,0.00004135973,0.00005352348,0.002333582],"study_design_scores_gemma":[0.00005886566,0.00152046,0.005469196,0.00001233555,0.00004027745,0.0002009046,0.00006495608,0.0002744012,0.989754,0.00003651832,0.002561464,0.000006652123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894508,0.006544754,0.0003993091,0.0001010691,0.00004225413,0.00003928203,0.0003717128,0.00004061731,0.003010281],"genre_scores_gemma":[0.9934872,0.002753527,0.0005411413,0.00008681138,0.00001642832,0.00004121148,0.0004715131,0.000006313576,0.002595812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962597,"threshold_uncertainty_score":0.006565571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421927825731236,"score_gpt":0.3083848925635425,"score_spread":0.2741656143062301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}