{"id":"W2107007476","doi":"10.2337/db11-0305","title":"Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Prohormone convertase; Compound heterozygosity; Heterozygote advantage; Mutation; Biology; Nonsynonymous substitution; Genetics; Exon; Endocrinology; Gene; Internal medicine; Allele; Prohormone; Medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831197,0.0005820586,0.0002900541,0.0008160391,0.0002900936,0.0002171089,0.0001525648,0.0003166898,0.00187202],"category_scores_gemma":[0.0007075331,0.0001860068,0.0001818981,0.0004011029,0.0003991396,0.0001325941,0.0003088894,0.0002481142,0.0002759878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007274964,"about_ca_system_score_gemma":0.0001108069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006209769,"about_ca_topic_score_gemma":0.0005486369,"domain_scores_codex":[0.999797,0.00004360772,0.00002713212,0.00006055949,0.00004363309,0.00002795401],"domain_scores_gemma":[0.9997442,0.00007275838,0.0000947224,0.00001889257,0.00001955056,0.00004978104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002096149,0.0001960969,0.7428781,0.0001712274,0.0005277209,0.02996721,0.0004715472,0.000576081,0.1851148,0.0009118556,0.0008307498,0.0362584],"study_design_scores_gemma":[0.00007984878,0.0005356279,0.8836746,0.00003662678,0.0002656818,0.09769403,0.0002443512,0.0008430854,0.01310005,0.0004874257,0.003010924,0.00002775724],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986176,0.0004564341,0.0005004405,0.00002083998,0.000006151356,0.000004068339,0.00009259619,0.00001477077,0.0002870515],"genre_scores_gemma":[0.9988326,0.0003179415,0.000354471,0.0000248447,0.00001314844,0.000002628435,0.0001330213,0.000008292351,0.0003129777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00187202,"threshold_uncertainty_score":0.0062626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161427764932745,"score_gpt":0.2289058349699639,"score_spread":0.2127630584766894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}