{"id":"W2107034951","doi":"10.1161/01.res.0000261934.56938.38","title":"cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular System","year":2007,"lang":"en","type":"review","venue":"Circulation Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Medical Research Council; Fondation Leducq; Heart and Stroke Foundation of Canada","keywords":"Phosphodiesterase; Enzyme; Chemistry; Biochemistry; Internal medicine; Endocrinology; Biology; Pharmacology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005034724,0.0003535921,0.0007480382,0.0004770969,0.0003153321,0.0001570535,0.000536364,0.0006411899,0.00002474728],"category_scores_gemma":[0.0001043832,0.000251022,0.0007415139,0.001011595,0.0001816049,0.000009299919,0.0001309981,0.0006685567,0.0001673948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661535,"about_ca_system_score_gemma":0.0002559332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005640032,"about_ca_topic_score_gemma":0.00003449802,"domain_scores_codex":[0.995419,0.001505231,0.000683701,0.0007740303,0.001056534,0.0005615086],"domain_scores_gemma":[0.9979519,0.0002001318,0.0001392743,0.00132616,0.0002928754,0.00008963385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004181614,0.0001095575,0.0001944825,0.008070577,0.0004582216,0.00009340225,0.0002620667,0.0005451167,0.00002882049,0.002014713,0.007817788,0.9803634],"study_design_scores_gemma":[0.00024905,0.00003388816,0.0004049494,0.001388222,0.0000633098,0.000119409,0.0002693101,0.00002835436,0.00003099622,0.000007030524,0.9971362,0.0002692626],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002436036,0.994517,0.000784283,0.00001573424,0.0004523841,0.001505898,0.00001763042,0.00002372033,0.002439752],"genre_scores_gemma":[0.01292831,0.9846033,0.00002593155,0.00002442015,0.0008163418,0.0003178408,0.0008703413,0.00006405051,0.000349389],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9893184,"threshold_uncertainty_score":0.9999942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1995087198904605,"score_gpt":0.4108901540509594,"score_spread":0.211381434160499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}