{"id":"W2107152679","doi":"10.2174/156652409789105543","title":"Prion Protein Misfolding","year":2009,"lang":"en","type":"review","venue":"Current Molecular Medicine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Neurodegeneration; Protein folding; Scrapie; Prion protein; Conformational change; Chemistry; Transmissible spongiform encephalopathy; Fibril; Gene isoform; Protein aggregation; Amyloid (mycology); Protein structure; Biophysics; Cell biology; Biology; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003735536,0.0006933904,0.001228284,0.0002031053,0.00009904611,0.0000293457,0.0005952045,0.0004041903,0.00009011928],"category_scores_gemma":[0.0003627345,0.0005550176,0.0006276722,0.0002990731,0.0001090944,0.000003423082,0.0001982782,0.0004382187,0.00004591608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005818475,"about_ca_system_score_gemma":0.0003037514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000245961,"about_ca_topic_score_gemma":3.779514e-7,"domain_scores_codex":[0.9971709,0.0002647165,0.0007257458,0.0009104334,0.000419195,0.0005090274],"domain_scores_gemma":[0.9982235,0.00001169458,0.0004419255,0.0009045337,0.00009098016,0.0003273357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00000917021,0.00004955621,3.077598e-7,0.004952439,0.00008866133,0.00002805271,0.000004970442,4.826646e-7,0.004209051,0.0001134121,0.001756579,0.9887873],"study_design_scores_gemma":[0.0003918545,0.0002723677,7.646186e-7,0.02247632,0.0005468882,0.00003776606,0.000002937704,0.000001530193,0.0005117887,0.0001005649,0.9751021,0.0005551095],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005045166,0.9955695,0.001929278,0.0000772044,0.0004499285,0.001600205,0.00001845347,0.00004406628,0.0002608874],"genre_scores_gemma":[0.00006496815,0.9968215,0.0002011043,0.0001073422,0.001225381,0.0002006025,0.001176125,0.00009476383,0.0001081967],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9882322,"threshold_uncertainty_score":0.9996901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0419746674501569,"score_gpt":0.3720043405127084,"score_spread":0.3300296730625515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}