{"id":"W2107152679","doi":"10.2174/156652409789105543","title":"Prion Protein Misfolding","year":2009,"lang":"en","type":"review","venue":"Current Molecular Medicine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Neurodegeneration; Protein folding; Scrapie; Prion protein; Conformational change; Chemistry; Transmissible spongiform encephalopathy; Fibril; Gene isoform; Protein aggregation; Amyloid (mycology); Protein structure; Biophysics; Cell biology; Biology; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003622031,0.001101403,0.001281276,0.001322065,0.0003686852,0.0009684897,0.0006533558,0.001232446,0.002358019],"category_scores_gemma":[0.0003026936,0.0002136815,0.0003293241,0.001070635,0.0005263838,0.0008279573,0.0007418999,0.0009980031,0.004151648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005043235,"about_ca_system_score_gemma":0.0004848542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005259221,"about_ca_topic_score_gemma":0.0007219088,"domain_scores_codex":[0.9998103,0.00002527602,0.00002245416,0.00004215687,0.00007799304,0.00002191423],"domain_scores_gemma":[0.9998629,0.00003762804,0.00003445863,0.00001084837,0.00003657627,0.00001754016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006673665,0.00006956975,0.0002839403,0.008106394,0.00009938633,0.001056229,0.0001035429,0.0003268235,0.01830207,0.005699165,0.03757194,0.9283141],"study_design_scores_gemma":[0.00001772488,0.0001232599,0.001190758,0.001155827,0.00006147732,0.008762376,0.00005972524,0.0001366649,0.008129488,0.0028488,0.9774948,0.00001901466],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008059141,0.9918157,0.0009616495,0.0002876226,0.0005287708,0.00002035678,0.00004165225,0.00004475061,0.005493525],"genre_scores_gemma":[0.007082311,0.9836757,0.0009779924,0.0004624377,0.0003571285,0.00002563754,0.0001161642,0.000006802095,0.007295758],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002358019,"threshold_uncertainty_score":0.007888377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0419746674501569,"score_gpt":0.3720043405127084,"score_spread":0.3300296730625515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}