{"id":"W2107156397","doi":"10.1083/jcb.200312018","title":"Misfolding diverts CFTR from recycling to degradation","year":2004,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Endosome; Cell biology; Ubiquitin; Endocytic cycle; Biology; TSG101; Endoplasmic-reticulum-associated protein degradation; Internalization; Endoplasmic reticulum; Lysosome; Protein targeting; Transmembrane protein; Mutant; Golgi apparatus; Protein folding; Membrane protein; Cell; Endocytosis; Biochemistry; Intracellular; Membrane; Unfolded protein response; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002212471,0.0001720865,0.000271044,0.0001751236,0.0001517727,0.0003907616,0.0001525605,0.0003739803,0.0007284016],"category_scores_gemma":[0.000257524,0.0001294394,0.000288272,0.0001225573,0.0002814938,0.0003227659,0.0002024589,0.0004613795,0.0002844743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004189081,"about_ca_system_score_gemma":0.0002200079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004535254,"about_ca_topic_score_gemma":0.0004516295,"domain_scores_codex":[0.9997835,0.00003873899,0.00002895556,0.00004617053,0.00005644381,0.00004621661],"domain_scores_gemma":[0.9998062,0.00004612027,0.00004107839,0.00004731761,0.00002907771,0.00003015045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009636227,0.000009072782,0.0005323935,0.00002581262,0.00000419852,0.0001942055,0.00001853083,0.0001640344,0.9967226,0.0004461042,0.00005613947,0.001730613],"study_design_scores_gemma":[0.00001286492,0.0001366172,0.005346889,0.000006104667,0.000008451212,0.001548944,0.00005819187,0.001310716,0.988581,0.000319418,0.00266424,0.000006545019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995673,0.00133217,0.002037378,0.0002085851,0.00002988024,0.000008525415,0.00009526016,0.00006149063,0.0005536389],"genre_scores_gemma":[0.9974,0.0005598544,0.001075326,0.0000946104,0.000007138119,0.000007684772,0.0001040972,0.00001837103,0.0007328219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007284016,"threshold_uncertainty_score":0.00303936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194848099263718,"score_gpt":0.2311147337041485,"score_spread":0.2191662527115113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}