{"id":"W2107179956","doi":"10.1002/phy2.86","title":"Nephrin missense mutations: induction of endoplasmic reticulum stress and cell surface rescue by reduction in chaperone interactions","year":2013,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada","keywords":"Nephrin; Calnexin; Endoplasmic reticulum; Unfolded protein response; Cell biology; ER retention; Podocyte; Biology; Mutant; Chemistry; Calreticulin; Biochemistry; Endocrinology; Kidney","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105901,0.0004315714,0.0003446077,0.000169851,0.0001397213,0.0001705869,0.0002086287,0.0004380034,0.001378477],"category_scores_gemma":[0.0001346427,0.0001421458,0.0002341378,0.0001282666,0.0002300755,0.0001251222,0.0002055422,0.0003827809,0.0002586959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001927559,"about_ca_system_score_gemma":0.0001727472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004147004,"about_ca_topic_score_gemma":0.0006689541,"domain_scores_codex":[0.9998587,0.00002392221,0.00002075751,0.00002887658,0.00004219797,0.00002551034],"domain_scores_gemma":[0.9998903,0.00001969175,0.00002915374,0.00001524897,0.000008581824,0.00003697728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395124,0.00003965817,0.0001096152,0.0000222424,0.000008567746,0.0004048497,0.000009703558,0.00003941779,0.998134,0.0000766726,0.00004906017,0.0009667539],"study_design_scores_gemma":[0.00005253999,0.0004726933,0.004675059,0.000005561278,0.00002544589,0.002182651,0.00001928421,0.0007210074,0.9898837,0.00005552701,0.001900121,0.000006397098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968371,0.0008103431,0.00106791,0.0000772251,0.00004020233,0.00002999448,0.0002557228,0.00009240236,0.0007889944],"genre_scores_gemma":[0.9955967,0.0006221013,0.001222425,0.00004352891,0.00001476704,0.00003313218,0.0003640282,0.00003508912,0.002068299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378477,"threshold_uncertainty_score":0.004611492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442861025013195,"score_gpt":0.2618915622122708,"score_spread":0.2474629519621388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}