{"id":"W2107187874","doi":"10.1093/toxsci/kfu075","title":"Intracerebroventricularly and Systemically Delivered Inhibitor of Brain CYP2B (C8-Xanthate), Even Following Chlorpyrifos Exposure, Reduces Chlorpyrifos Activation and Toxicity in Male Rats","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Pesticide Exposure and Toxicity","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Chlorpyrifos; Toxicity; Pharmacology; Neurotoxicity; Chemistry; Organophosphate; Xanthate; Medicine; Pesticide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040244,0.001012851,0.000403808,0.0004760659,0.0002090505,0.0002656099,0.000339922,0.0004200872,0.002042438],"category_scores_gemma":[0.00010199,0.0002828627,0.0002930279,0.0002204644,0.0004700381,0.0003803917,0.0001766885,0.001027457,0.0004376453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925723,"about_ca_system_score_gemma":0.0004423941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002630471,"about_ca_topic_score_gemma":0.005087835,"domain_scores_codex":[0.9998845,0.000009250069,0.000008457109,0.00002896484,0.00002361513,0.00004521814],"domain_scores_gemma":[0.9998161,0.000009428456,0.0000766766,0.00001494957,0.00002133554,0.00006152396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001863112,0.0004086651,0.0003887785,0.00007208372,0.00001995842,0.00007669738,0.00003270977,0.00009057557,0.9940556,0.00007535062,0.0001495696,0.002766995],"study_design_scores_gemma":[0.0001465415,0.004469496,0.00668723,0.00001175431,0.00005859422,0.0002008678,0.0000658724,0.0006143647,0.986513,0.00004630245,0.001177002,0.000009070893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957336,0.0009496159,0.001184637,0.0001424468,0.00004670399,0.00003784615,0.000608906,0.0002224049,0.001073924],"genre_scores_gemma":[0.9881188,0.001413203,0.001572918,0.00006727532,0.00003015886,0.00008953312,0.0007662412,0.00003198841,0.007909938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002630471,"threshold_uncertainty_score":0.006832659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01655586108341459,"score_gpt":0.2277060849210742,"score_spread":0.2111502238376596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}