{"id":"W2107233903","doi":"10.1093/annonc/mdp254","title":"Small molecules and targeted therapies in distant metastatic disease","year":2009,"lang":"en","type":"review","venue":"Annals of Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Sunitinib; Everolimus; Targeted therapy; Sorafenib; Cancer research; Imatinib; Temsirolimus; Axitinib; Melanoma; Trametinib; Pazopanib; Pharmacology; Tyrosine kinase; Oncology; PI3K/AKT/mTOR pathway; Internal medicine; Cancer; Kinase; MAPK/ERK pathway; Signal transduction; Biology; Receptor; Discovery and development of mTOR inhibitors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002553879,0.0002860248,0.001070618,0.0001201102,0.0000203257,0.000007452875,0.0001977732,0.0001877185,0.00000965694],"category_scores_gemma":[0.0001177682,0.0002276998,0.0002360994,0.00009035142,0.0001207573,0.000001731054,0.00008734947,0.0001261015,0.000002713969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007551289,"about_ca_system_score_gemma":0.0003629515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001321278,"about_ca_topic_score_gemma":0.00006049091,"domain_scores_codex":[0.9984685,0.0003290966,0.0004830821,0.0003899097,0.00006515527,0.0002642287],"domain_scores_gemma":[0.9991713,0.00005113003,0.0002859156,0.0003112277,0.00005324451,0.0001272107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007226168,0.0002150355,0.00001195057,0.002248267,0.0001719486,0.0001413846,0.00003128839,8.011772e-7,0.0003327153,0.0005562801,0.0006443577,0.9955737],"study_design_scores_gemma":[0.0002458835,0.001070833,0.00007484752,0.000567554,0.0001509575,0.00001843729,0.00001587607,0.000001759819,0.0001264664,0.0006316432,0.9968671,0.0002286661],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001699323,0.9969258,0.00005344387,0.0001455666,0.00007032001,0.0003777002,0.0001168496,0.000004845038,0.0006061918],"genre_scores_gemma":[0.001024675,0.9975699,0.0004841931,0.000263023,0.0000588098,0.00005652307,0.0004125517,0.00002460501,0.0001057459],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9962227,"threshold_uncertainty_score":0.928533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1244540794358548,"score_gpt":0.377092111462753,"score_spread":0.2526380320268983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}