{"id":"W2107275684","doi":"10.1158/0008-5472.can-04-3137","title":"Effects of the Mammalian Target of Rapamycin Inhibitor CCI-779 Used Alone or with Chemotherapy on Human Prostate Cancer Cells and Xenografts","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"DU145; PTEN; Cancer research; Clonogenic assay; Mitoxantrone; Protein kinase B; LNCaP; PI3K/AKT/mTOR pathway; Chemotherapy; Docetaxel; Cell growth; Prostate cancer; Cell culture; Medicine; Cancer; Biology; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002376974,0.0005096029,0.0005769713,0.0003565768,0.0002065384,0.0003473763,0.0002752487,0.000304798,0.001319186],"category_scores_gemma":[0.0001647097,0.0002024705,0.00032398,0.0004619677,0.0002248387,0.0002248885,0.0001425582,0.0008547487,0.0003179307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005641093,"about_ca_system_score_gemma":0.0006466318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003865295,"about_ca_topic_score_gemma":0.006302802,"domain_scores_codex":[0.9996922,0.00007540718,0.00003007792,0.00004013134,0.00008072331,0.00008155747],"domain_scores_gemma":[0.9997827,0.0000608041,0.00003785042,0.00002707817,0.00002370578,0.0000677218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001937921,0.0008575808,0.0008388326,0.0001876704,0.00005271461,0.000121923,0.00007157062,0.0008078265,0.9879093,0.000229521,0.0005518234,0.006433445],"study_design_scores_gemma":[0.0001162445,0.005981309,0.005380589,0.0000118538,0.00005082917,0.0002201287,0.00005215681,0.001817436,0.9837804,0.00002079276,0.00255672,0.00001160302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932318,0.003376849,0.0004297487,0.00008758101,0.00008773508,0.0000642626,0.0005558288,0.00007265238,0.002093566],"genre_scores_gemma":[0.9927257,0.00245067,0.001562341,0.00004480004,0.0000246543,0.00008214537,0.001206685,0.00002568203,0.001877362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003865295,"threshold_uncertainty_score":0.007685602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02592769367430632,"score_gpt":0.3528138193022078,"score_spread":0.3268861256279015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}