{"id":"W2107293885","doi":"10.1038/sj.bjp.0705476","title":"Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice","year":2003,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Toronto General Hospital; University of Calgary","funders":"","keywords":"Endocrinology; Internal medicine; Biopterin; Endothelial dysfunction; Tetrahydrobiopterin; Oxidative stress; Chemistry; Malondialdehyde; Endothelium; Mesenteric arteries; Lipid peroxidation; Nitric oxide; Nitric oxide synthase; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073223,0.0006734369,0.0006995941,0.0005991449,0.000213814,0.0003323944,0.0002988831,0.0004724735,0.001063574],"category_scores_gemma":[0.0001678165,0.0002940524,0.0003929999,0.000206365,0.0002785048,0.0002565861,0.0002389448,0.001219585,0.0003148057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000194178,"about_ca_system_score_gemma":0.0001622485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006440391,"about_ca_topic_score_gemma":0.0009273599,"domain_scores_codex":[0.9998565,0.00002259648,0.00002290566,0.00003719913,0.0000251593,0.00003566777],"domain_scores_gemma":[0.9997008,0.00001915082,0.0001104888,0.00002065284,0.00003479792,0.0001141105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001625629,0.0003341228,0.0004437733,0.00007830533,0.00002567223,0.00008627323,0.00001905037,0.00003171863,0.9950505,0.00002766881,0.00004732047,0.002229972],"study_design_scores_gemma":[0.0004596872,0.009312071,0.03173423,0.00004219391,0.0002645495,0.000757026,0.0001132406,0.0008770904,0.9530061,0.0001131908,0.003299323,0.00002120045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959716,0.001587808,0.001210267,0.0001226148,0.0000398619,0.00003209935,0.0003425888,0.000115264,0.0005778796],"genre_scores_gemma":[0.9879996,0.002645246,0.003851953,0.000253196,0.00005622374,0.000119462,0.001131616,0.00005131444,0.003891411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063574,"threshold_uncertainty_score":0.00355804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272238116258459,"score_gpt":0.2768449705362588,"score_spread":0.2641225893736742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}