{"id":"W2107307011","doi":"10.1038/sj.emboj.7601896","title":"Niche‐mediated control of human embryonic stem cell self‐renewal and differentiation","year":2007,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":388,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Centre for Phenogenomics; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Stem Cell Network","keywords":"Biology; Embryonic stem cell; Cell biology; Niche; Endoderm; Bone morphogenetic protein 2; Stem cell niche; Cellular differentiation; Micropatterning; Bone morphogenetic protein; Stem cell; Genetics; Biochemistry; Progenitor cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009015983,0.00009818932,0.0001263079,0.00005281044,0.0001541285,0.00002830505,0.0002124676,0.00007809579,0.00001720455],"category_scores_gemma":[0.00001284264,0.00006754353,0.00006550598,0.00005631065,0.0000619384,0.00000334389,0.00006873169,0.0002001181,0.000004127792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001701036,"about_ca_system_score_gemma":0.00004912677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003636788,"about_ca_topic_score_gemma":0.00001321135,"domain_scores_codex":[0.9990065,0.0001390187,0.0002403645,0.0001234816,0.0002337505,0.0002569541],"domain_scores_gemma":[0.9993988,0.00004312042,0.0001740383,0.0001730471,0.0001061868,0.0001047958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009064376,0.0000601859,0.00595887,0.00001655875,0.00007038335,0.000005257665,0.00008998893,0.000008889353,0.9931081,0.00001340207,0.0001919552,0.0003857509],"study_design_scores_gemma":[0.003160027,0.0006088966,0.04204338,0.00001995726,0.00007658332,0.0001695772,0.0002531759,0.0002556948,0.9518963,0.0001472203,0.001190479,0.0001787324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961766,0.001536054,0.001324708,0.0001140615,0.00008143607,0.0001196934,0.000005454213,0.000004858119,0.0006371097],"genre_scores_gemma":[0.9988204,0.0002921285,0.000022341,0.0000443143,0.0002003531,0.000001259768,0.00001058517,0.00001308055,0.000595539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04121183,"threshold_uncertainty_score":0.2754345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00886544804301488,"score_gpt":0.2498586578772689,"score_spread":0.240993209834254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}