{"id":"W2107307011","doi":"10.1038/sj.emboj.7601896","title":"Niche‐mediated control of human embryonic stem cell self‐renewal and differentiation","year":2007,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":388,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Centre for Phenogenomics; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Stem Cell Network","keywords":"Biology; Embryonic stem cell; Cell biology; Niche; Endoderm; Bone morphogenetic protein 2; Stem cell niche; Cellular differentiation; Micropatterning; Bone morphogenetic protein; Stem cell; Genetics; Biochemistry; Progenitor cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000211989,0.0002005761,0.0001704472,0.000245556,0.0001691136,0.0005055917,0.0002314111,0.0001797069,0.001293772],"category_scores_gemma":[0.0002219317,0.0001134906,0.0001801008,0.0001505282,0.000243742,0.0002556023,0.0005621747,0.0003584763,0.0002694185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473195,"about_ca_system_score_gemma":0.0002660161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006244646,"about_ca_topic_score_gemma":0.001672849,"domain_scores_codex":[0.9998098,0.00002563422,0.000009651285,0.00003194426,0.00005368326,0.00006940269],"domain_scores_gemma":[0.9998685,0.0000256867,0.0000242961,0.00001448398,0.00001853303,0.00004852559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001351718,0.00001167743,0.0002344569,0.00004524522,0.000004297416,0.00006091842,0.00003380927,0.00006914154,0.9940218,0.001195562,0.000132276,0.00405567],"study_design_scores_gemma":[0.00002537509,0.0001312174,0.008500726,0.00001186803,0.00001386178,0.0004199655,0.00008154436,0.001642303,0.9791469,0.0005098536,0.009508361,0.000008120031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755343,0.009900715,0.006114691,0.0002267471,0.0001205628,0.00002030857,0.0005636226,0.0003149075,0.007204084],"genre_scores_gemma":[0.9949257,0.0008669702,0.001121782,0.00004204961,0.00001518486,0.00001061438,0.0002234824,0.0000547023,0.002739582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293772,"threshold_uncertainty_score":0.004328132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00886544804301488,"score_gpt":0.2498586578772689,"score_spread":0.240993209834254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}