{"id":"W2107312445","doi":"10.25011/cim.v35i5.18697","title":"Advances in Molecular Targets for the Treatment of Medulloblastomas","year":2012,"lang":"en","type":"review","venue":"Clinical and investigative medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital de l'Enfant-Jésus; Université Laval","funders":"","keywords":"Medulloblastoma; Wnt signaling pathway; Cancer research; PI3K/AKT/mTOR pathway; Biology; Hedgehog; Signal transduction; Receptor tyrosine kinase; Targeted therapy; Medicine; Bioinformatics; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001083519,0.0005641801,0.0006937754,0.003175036,0.0001560563,0.0009329742,0.0003953371,0.0005014978,0.004142676],"category_scores_gemma":[0.0008354954,0.0001385485,0.0008043212,0.002000987,0.0002240025,0.001071468,0.000513943,0.001034169,0.001608443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005399333,"about_ca_system_score_gemma":0.0007003399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003430667,"about_ca_topic_score_gemma":0.001052268,"domain_scores_codex":[0.9996828,0.00006786469,0.00006435345,0.00003019755,0.0001235028,0.00003135774],"domain_scores_gemma":[0.9995697,0.0001755248,0.0001064058,0.00002065803,0.00009664794,0.00003104476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007225548,0.0003265459,0.0006479003,0.01779885,0.0002412738,0.0004294682,0.0001020785,0.0005974458,0.02989291,0.005782806,0.009940924,0.9335172],"study_design_scores_gemma":[0.00059701,0.002873839,0.008390462,0.007307938,0.0009366765,0.002858963,0.0001791018,0.0006106333,0.01843913,0.007347597,0.9504101,0.00004849277],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003952761,0.9872928,0.00141421,0.001774732,0.0004323307,0.00006294152,0.0003158945,0.00006734471,0.004686984],"genre_scores_gemma":[0.01237086,0.9817441,0.002880822,0.000587331,0.0005326134,0.00005312673,0.0004748465,0.00001383122,0.001342534],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004142676,"threshold_uncertainty_score":0.01385862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2427324864907155,"score_gpt":0.4406265424399169,"score_spread":0.1978940559492015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}