{"id":"W2107337979","doi":"10.1128/mcb.24.11.4636-4650.2004","title":"Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Children’s Health Research Institute","funders":"","keywords":"Fusion protein; Biology; ETV6; Chimeric gene; Fusion gene; Mutant; Tyrosine kinase; Molecular biology; Tyrosine; Protein kinase domain; Transformation (genetics); Cell biology; Gene; Signal transduction; Biochemistry; Chromosomal translocation; Recombinant DNA; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000123962,0.0004339857,0.0002166308,0.0001576787,0.0001344564,0.0001722866,0.0002884235,0.0003056405,0.001626301],"category_scores_gemma":[0.000134842,0.0001530353,0.000310337,0.0001477133,0.0002602398,0.0001475045,0.0002236775,0.0005229115,0.0004741627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003877732,"about_ca_system_score_gemma":0.0002094118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004708372,"about_ca_topic_score_gemma":0.0007066352,"domain_scores_codex":[0.9998299,0.00003802888,0.00002298737,0.00002525965,0.00004505318,0.0000387555],"domain_scores_gemma":[0.9998738,0.00003718063,0.00003951091,0.00001459871,0.000005372871,0.0000296115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001148158,0.00003522442,0.0001460496,0.00001271731,0.000004702313,0.00007995193,0.000009830163,0.0001339648,0.998542,0.0002044953,0.00001641322,0.0006998111],"study_design_scores_gemma":[0.00001879975,0.000150709,0.001918424,0.000002718284,0.000007077566,0.0003230328,0.000008456386,0.001164435,0.9946786,0.00003042504,0.001694082,0.000003241898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964729,0.0002555034,0.001963364,0.00003258917,0.00001412024,0.00002483887,0.0001854313,0.00005385501,0.0009973175],"genre_scores_gemma":[0.996847,0.0001445234,0.001447423,0.00001379702,0.000002700351,0.00002202365,0.0002424729,0.00002208093,0.001257924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001626301,"threshold_uncertainty_score":0.005440533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108973834210987,"score_gpt":0.2835636639335447,"score_spread":0.272666280512446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}