{"id":"W2107337979","doi":"10.1128/mcb.24.11.4636-4650.2004","title":"Mutations in the SAM Domain of the ETV6-NTRK3 Chimeric Tyrosine Kinase Block Polymerization and Transformation Activity","year":2004,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Children’s Health Research Institute","funders":"","keywords":"Fusion protein; Biology; ETV6; Chimeric gene; Fusion gene; Mutant; Tyrosine kinase; Molecular biology; Tyrosine; Protein kinase domain; Transformation (genetics); Cell biology; Gene; Signal transduction; Biochemistry; Chromosomal translocation; Recombinant DNA; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212438,0.00007420751,0.0001244471,0.00006371558,0.00006481859,0.000006983171,0.00005999608,0.00007466606,0.000006390685],"category_scores_gemma":[0.00003023913,0.00004557601,0.00003389072,0.0002773522,0.0002260166,0.00002077268,0.00001804417,0.0001430102,6.368718e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002134759,"about_ca_system_score_gemma":0.00006964502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002681089,"about_ca_topic_score_gemma":0.00003442565,"domain_scores_codex":[0.9993232,0.0001822858,0.0001296789,0.0001264578,0.0001045378,0.0001337851],"domain_scores_gemma":[0.9997271,0.00002354338,0.00003730422,0.0001599749,0.00002140268,0.00003066554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004284683,0.00007403482,0.001590339,0.00004616175,0.00001264693,0.000008068592,0.001111005,0.00002730152,0.9902467,0.002335526,0.000001134428,0.004504306],"study_design_scores_gemma":[0.001809559,0.0003733658,0.02585435,0.000047907,0.00004720392,0.00007415352,0.0003334667,0.000149441,0.9687027,0.002054655,0.0004678295,0.00008533333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860818,0.00118401,0.007650725,0.004286475,0.0000270977,0.0004221381,0.000009470222,0.00000521355,0.0003330395],"genre_scores_gemma":[0.9994844,0.00008753002,0.00009992941,0.0002501711,0.00001350442,0.00002214552,0.00003002293,0.000006612844,0.000005737806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02426401,"threshold_uncertainty_score":0.1858536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0108973834210987,"score_gpt":0.2835636639335447,"score_spread":0.272666280512446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}