{"id":"W2107383745","doi":"10.1126/science.1232552","title":"Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; Provincial Health Services Authority; Simon Fraser University; University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Australian Synchrotron; Michael Smith Health Research BC; National Health and Medical Research Council; Pfizer","keywords":"Neuraminidase; Mechanism (biology); Virology; Broad spectrum; Neuraminidase inhibitor; Chemistry; Virus; Biology; Medicine; Coronavirus disease 2019 (COVID-19); Combinatorial chemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004022085,0.000570911,0.0002434461,0.0001552171,0.0001723188,0.0003181721,0.0005545724,0.0003999027,0.001323071],"category_scores_gemma":[0.0002087772,0.000155412,0.0003836994,0.0001025266,0.0002628724,0.000371597,0.0002965963,0.0004885505,0.0003326312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002436606,"about_ca_system_score_gemma":0.0002656745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001629167,"about_ca_topic_score_gemma":0.0004835512,"domain_scores_codex":[0.9998554,0.00003423567,0.00001193157,0.00002867968,0.00004343821,0.00002639275],"domain_scores_gemma":[0.999921,0.00001332353,0.00002874457,0.00001144532,0.00001240623,0.00001308148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002218556,0.0002013815,0.0004533901,0.0002093681,0.00004352839,0.0001756754,0.00003119818,0.0008438501,0.9782969,0.003246198,0.0002347765,0.01604202],"study_design_scores_gemma":[0.0001249699,0.002939749,0.0009343908,0.00001120323,0.00005646636,0.0007235853,0.00001493791,0.0008803534,0.9849554,0.0002552758,0.009091295,0.00001246888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9129893,0.01899981,0.0509118,0.0004252338,0.0002304774,0.0007154798,0.0004881287,0.0003045379,0.01493516],"genre_scores_gemma":[0.9787119,0.004601633,0.01293296,0.0001307599,0.00003715834,0.0001163791,0.000244943,0.00001206638,0.003212209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323071,"threshold_uncertainty_score":0.004426122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04795181266898127,"score_gpt":0.3447239603894916,"score_spread":0.2967721477205103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}