{"id":"W2107383745","doi":"10.1126/science.1232552","title":"Mechanism-Based Covalent Neuraminidase Inhibitors with Broad-Spectrum Influenza Antiviral Activity","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; Provincial Health Services Authority; Simon Fraser University; University of British Columbia","funders":"Medical Research Council; Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Australian Synchrotron; Michael Smith Health Research BC; National Health and Medical Research Council; Pfizer","keywords":"Neuraminidase; Mechanism (biology); Virology; Broad spectrum; Neuraminidase inhibitor; Chemistry; Virus; Biology; Medicine; Coronavirus disease 2019 (COVID-19); Combinatorial chemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006151281,0.0002193439,0.0002756967,0.0003390003,0.0004593636,0.00013863,0.0002947834,0.00004764343,0.0001076429],"category_scores_gemma":[0.0004308184,0.0001495326,0.00005732322,0.001265681,0.001617214,0.0007052066,0.0001910924,0.000347039,0.0003624635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002250386,"about_ca_system_score_gemma":0.000765505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002698853,"about_ca_topic_score_gemma":0.00002635539,"domain_scores_codex":[0.9968972,0.00004984888,0.0001813951,0.0005730352,0.001459128,0.0008394176],"domain_scores_gemma":[0.9986408,0.00008642684,0.00008752953,0.0005398574,0.0003407733,0.0003046558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005944707,0.0005539216,0.06952379,0.0001764803,0.00004828248,0.0001437599,0.000577174,0.00006209681,0.9128116,0.0008053832,0.0005740171,0.01412901],"study_design_scores_gemma":[0.001741099,0.001285025,0.2337412,0.0001215754,0.00002169415,0.00001420675,0.0001505142,0.003060577,0.7584074,0.000198612,0.0009932229,0.0002649353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953294,0.00005319524,0.0002194925,0.001645066,0.0001225314,0.0008895458,0.000005786049,0.0001244121,0.001610552],"genre_scores_gemma":[0.9971883,0.000006387764,0.0007831879,0.001662109,0.00007620557,0.00008206212,5.215124e-7,0.00001721648,0.000184013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1642174,"threshold_uncertainty_score":0.6097762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04795181266898127,"score_gpt":0.3447239603894916,"score_spread":0.2967721477205103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}