{"id":"W2107395755","doi":"10.1091/mbc.e12-02-0102","title":"Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum","year":2012,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Protein disulfide-isomerase; Biology; Unfolded protein response; Biochemistry; Oxidative folding; Secretory protein; Secretory pathway; Secretion; Cell biology; Oxidative phosphorylation; Protein folding; Golgi apparatus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001894835,0.0004231693,0.0002891011,0.0002576323,0.0002180501,0.0004868771,0.0002772694,0.0003297259,0.0003691232],"category_scores_gemma":[0.0001444691,0.0001611575,0.0001629701,0.0001770815,0.000355752,0.0002809857,0.0003008822,0.0003105975,0.0002050917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003863351,"about_ca_system_score_gemma":0.0002592863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005211242,"about_ca_topic_score_gemma":0.0004285813,"domain_scores_codex":[0.9998562,0.00002531156,0.00001453711,0.00004866176,0.00003122072,0.00002401942],"domain_scores_gemma":[0.9999068,0.0000142123,0.00002899329,0.00001540462,0.0000170775,0.00001759359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005701,0.0000126518,0.0006923918,0.00004133272,0.00000561055,0.00007281884,0.00001452634,0.00009362046,0.9965315,0.0002571435,0.0000201967,0.002157569],"study_design_scores_gemma":[0.00001189758,0.0001430014,0.007115421,0.000006168542,0.00003452846,0.0005518498,0.00004742161,0.0008593626,0.9867194,0.0003077019,0.004195213,0.000007904122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980056,0.007291791,0.01050086,0.0002961971,0.00003882076,0.00002977882,0.0001946421,0.0001256434,0.001466329],"genre_scores_gemma":[0.9898146,0.003468982,0.004523383,0.00002984094,0.00001141041,0.00001250154,0.0002195434,0.00001304834,0.001906594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005211242,"threshold_uncertainty_score":0.002803147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003923458031361417,"score_gpt":0.2212588211795407,"score_spread":0.2173353631481793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}