{"id":"W2107400826","doi":"10.1158/0008-5472.can-11-2126","title":"Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; Neoplastic transformation; Carcinogenesis; MAPK/ERK pathway; Nuclear localization sequence; Cell biology; Biology; Phosphorylation; Cancer research; Nuclear export signal; Signal transduction; Kinase; Subcellular localization; Malignant transformation; Cancer; Cell growth; Cell nucleus; Nucleus; Genetics; Cytoplasm; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007868023,0.0003187742,0.0001944207,0.0002013579,0.000138863,0.0002472847,0.0001650104,0.0002226035,0.0009716373],"category_scores_gemma":[0.000080417,0.000165259,0.0001928918,0.0001026507,0.0002495792,0.0001598511,0.0001987674,0.0005701434,0.0002500961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002907474,"about_ca_system_score_gemma":0.0001945928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008989816,"about_ca_topic_score_gemma":0.001916315,"domain_scores_codex":[0.9999014,0.00001433073,0.00001241078,0.00001779333,0.0000280208,0.00002603594],"domain_scores_gemma":[0.9999148,0.0000192615,0.00002284338,0.00001404163,0.000006026272,0.00002301554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002386377,0.000009885953,0.00006610126,0.000006969235,0.000001621993,0.00003914824,0.000006686217,0.00003275609,0.9994769,0.00006277853,0.000007912457,0.0002654855],"study_design_scores_gemma":[0.000006223655,0.0001119031,0.00180721,0.000001621911,0.00000446525,0.0002524118,0.00002209784,0.0006166401,0.9962572,0.0000358094,0.0008821862,0.000002273198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972736,0.0004242288,0.001362513,0.00006200555,0.00001234393,0.00001083082,0.00009186156,0.00005391947,0.0007086097],"genre_scores_gemma":[0.9973485,0.0002799924,0.0007692992,0.00001789198,0.00000264158,0.00001260518,0.0001234083,0.00001071871,0.001434881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009716373,"threshold_uncertainty_score":0.00325048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04321457610070474,"score_gpt":0.3559262528742646,"score_spread":0.3127116767735599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}