{"id":"W2107409113","doi":"10.1093/hmg/ddq101","title":"CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases","keywords":"CIITA; Biology; Single-nucleotide polymorphism; Haplotype; Multiple sclerosis; Odds ratio; MHC class II; Genetics; Allele; Major histocompatibility complex; Immunology; Internal medicine; Gene; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004789609,0.000471784,0.0004824766,0.000664239,0.0004308831,0.0005221472,0.0003778318,0.0007860523,0.005287595],"category_scores_gemma":[0.00167884,0.0002384573,0.0004060308,0.0009693663,0.0003256767,0.0001621409,0.0003294767,0.0005239839,0.0005306719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373174,"about_ca_system_score_gemma":0.0001555353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003153525,"about_ca_topic_score_gemma":0.002613346,"domain_scores_codex":[0.9994324,0.0001727592,0.00003888504,0.0002379327,0.00005960783,0.00005849496],"domain_scores_gemma":[0.9991664,0.0002286453,0.0003673784,0.00008642767,0.00004353028,0.0001077194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002208963,0.000188734,0.940904,0.0001095554,0.0008743815,0.001012256,0.0002348076,0.0002862044,0.03959575,0.0003732295,0.001191107,0.01302113],"study_design_scores_gemma":[0.00003842335,0.0002036303,0.9947174,0.00001903912,0.0002487475,0.002286268,0.00004664369,0.000445356,0.0008392891,0.0002173887,0.000927752,0.00001003238],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974495,0.0007225244,0.0003822636,0.00007353334,0.00001190763,0.00001176318,0.0003726144,0.00003595086,0.0009398956],"genre_scores_gemma":[0.9977552,0.0002525766,0.0009016471,0.00006608041,0.00002726998,0.00001302596,0.0004225567,0.00001701257,0.0005446484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005287595,"threshold_uncertainty_score":0.01768875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975165358367985,"score_gpt":0.231659211947366,"score_spread":0.2119075583636862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}