{"id":"W2107409113","doi":"10.1093/hmg/ddq101","title":"CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases","keywords":"CIITA; Biology; Single-nucleotide polymorphism; Haplotype; Multiple sclerosis; Odds ratio; MHC class II; Genetics; Allele; Major histocompatibility complex; Immunology; Internal medicine; Gene; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003601884,0.000145797,0.0001969574,0.00008991529,0.0001773443,0.00001365342,0.0004600878,0.0002698039,0.00008557419],"category_scores_gemma":[0.0002848345,0.0001190166,0.00009880088,0.0001068203,0.0002746106,0.0000224301,0.00009253577,0.0003255175,0.0000261542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006816726,"about_ca_system_score_gemma":0.0000327923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006111531,"about_ca_topic_score_gemma":0.0005645221,"domain_scores_codex":[0.9988256,0.0002929617,0.0003105529,0.0002534692,0.00004210015,0.0002753677],"domain_scores_gemma":[0.9988688,0.0003143112,0.000182745,0.0005329907,0.00008990079,0.0000112815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004475969,0.0002822611,0.006280145,0.00001216932,0.00005831381,0.000001303524,0.0005078886,0.00004087911,0.9904433,0.001340434,0.0002317966,0.0007567685],"study_design_scores_gemma":[0.002106228,0.0003438622,0.1499219,0.00001627544,0.000102447,0.00001238838,0.0001415929,0.00008092271,0.8408825,0.002280711,0.003918703,0.0001923967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996002,0.00150522,0.001499186,0.00004608387,0.0002528776,0.0004786221,0.00005576302,0.00001778602,0.0001424529],"genre_scores_gemma":[0.9986619,0.0001138352,0.0008532672,0.00007938941,0.0000238591,0.00006961086,0.00008579841,0.0000174368,0.0000948715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1495607,"threshold_uncertainty_score":0.4853355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975165358367985,"score_gpt":0.231659211947366,"score_spread":0.2119075583636862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}