{"id":"W2107413660","doi":"10.1373/clinchem.2015.238105","title":"Clopidogrel and CYP2C19: Pharmacogenetic Testing Ready for Clinical Prime Time?","year":2015,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University Health Network; Western University; Mount Sinai Hospital; University of Toronto","funders":"Eli Lilly and Company","keywords":"CYP2C19; Clopidogrel; Pharmacogenetics; Medicine; Prime (order theory); Internal medicine; Pharmacology; Biology; Genotype; Aspirin; Mathematics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004763672,0.0006673345,0.001000724,0.001067536,0.0005052651,0.002142908,0.0007653247,0.006322038,0.01091495],"category_scores_gemma":[0.01606472,0.0003985522,0.0006203316,0.0007866069,0.001258105,0.004193368,0.001330286,0.007690216,0.006188328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008920697,"about_ca_system_score_gemma":0.001846062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001764003,"about_ca_topic_score_gemma":0.002275856,"domain_scores_codex":[0.9973235,0.000815914,0.0003623615,0.0003584464,0.0009607152,0.0001790379],"domain_scores_gemma":[0.9923786,0.003314416,0.0008902374,0.0002425421,0.002234808,0.0009394677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003051127,0.00005710794,0.002930198,0.0005932671,0.00004554302,0.001373085,0.0001775362,0.0001052602,0.001674311,0.00452066,0.6656836,0.3225343],"study_design_scores_gemma":[0.0000975019,0.0001834813,0.003400806,0.001513793,0.00005368016,0.00431115,0.0001774642,0.0002211237,0.0006345795,0.01095767,0.9783863,0.00006240662],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001516173,0.1074369,0.0039869,0.8542814,0.02169757,0.00007409931,0.0002651524,0.0002359659,0.01050583],"genre_scores_gemma":[0.02770632,0.2072207,0.01627717,0.5768167,0.1437086,0.0001921624,0.0008925773,0.0003785259,0.02680723],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01091495,"threshold_uncertainty_score":0.03651416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2920167579993943,"score_gpt":0.4709150393582577,"score_spread":0.1788982813588634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}